Review of Cardiovascular Manifestations of Hyperthyroidism: Main Triggered Heart Diseases and Clinical Implications

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Vitor Ohana Marques Azzini
Cristianne Confessor Castilho Lopes
Natascha Szumsztajn Beker
Eduardo Barbosa Lopes
Lucas Castilho Lopes
Maria Eduarda Castilho Lopes
Fábio Herget Pitanga
Mushue Dayan Hampel Vieira Filho
Larissa Silva Guimarães
Fabio Kopp Vanuzzi

Abstract

Introduction: Hyperthyroidism, a common endocrinological condition characterized by excess production of thyroid hormones, has profound and varied effects on the cardiovascular system. The thyroid hormones, triiodothyronine (T3) and thyroxine (T4), play essential roles in regulating basal metabolism and cardiovascular function


Objective: To provide a comprehensive understanding of the various cardiac complications associated with hyperthyroidism and their clinical implications. Methods: This study constitutes a systematic review, classified as exploratory and descriptive. The preparation of the research was a bibliographical search in electronic databases on methods associated with RSL (Systematic Literature Review) and the applications of SMARTER (Simple Multi-Attribute Rating Technique using Exploiting Rankings).


Results: A comprehensive systematic search of the literature yielded a total of 5689 articles referring to the incidence of obesity and overweight in adolescents, of which 20 articles were eligible to be included in this systematic review.


Conclusion: Continuous research and therapeutic innovation play vital roles in the evolution of the treatment of hyperthyroidism and its cardiovascular complications. The development of personalized approaches that consider the genetic and clinical particularities of each patient can significantly improve quality of life and reduce associated morbidity and mortality.

Article Details

How to Cite
Vitor Ohana Marques Azzini, Cristianne Confessor Castilho Lopes, Natascha Szumsztajn Beker, Eduardo Barbosa Lopes, Lucas Castilho Lopes, Maria Eduarda Castilho Lopes, Fábio Herget Pitanga, Mushue Dayan Hampel Vieira Filho, Larissa Silva Guimarães, & Fabio Kopp Vanuzzi. (2024). Review of Cardiovascular Manifestations of Hyperthyroidism: Main Triggered Heart Diseases and Clinical Implications. International Journal of Medical Science and Clinical Research Studies, 4(06), 1049–1053. https://doi.org/10.47191/ijmscrs/v4-i06-09
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References

I. ALSAIDAN, A.; ALRUWIALI, F. Association between hyperthyroidism and thromboembolism: A retrospective observational study. Annals of African Medicine , vol. 22, no. 2, p. 183, 2023.

II. ANTONIJEVIC, N.; MATIC, D.; BELESLIN, B.; MIKOVIC, D.; LEKOVIC, Z.; MARJANOVIC, M.; USCUMLIC, A.; BIROVLJEV, L.; JAKOVLJEVIC, B. The Influence of Hyperthyroidism on the Coagulation and on the Risk of Thrombosis. Journal of Clinical Medicine , vol. 13, no. 6, p. 1756, 19 Mar. 2024.

III. CHO, YY; Kim, B.; CHOI, D.; KIM, C.-H.; SHIN, DW; KIM, JS; PARK, S.-J.; KIM, SW; CHUNG, JH; HAN, K.; KIM, TH Graves' disease, its treatments, and the risk of atrial fibrillation: A Korean population-based study. Frontiers in Endocrinology , vol. 13, p. 1032764, 1 Nov. 2022.

IV. DUGGIRALA, N.; GUJJARLAPUDI, RC; JAFRI, GZ; BASNYAT, A.; MAHARJAN, S.; ABDIN, Z. AL; ASSEFI, M. Cardiovascular Complications of Hyperthyroidism. Journal of Critical Care & Emergency Medicine , vol. 123, p. 1–7, 28 Feb. 2023.

V. ELMENYAR, E.; AOUN, S.; AL SAADI, Z.; BARKUMI, A.; CANDER, B.; AL-THANI, H.; EL-MENYAR, A. Data Analysis and Systematic Scoping Review on the Pathogenesis and Modalities of Treatment of Thyroid Storm Complicated with Myocardial Involvement and Shock. Diagnostics , vol. 13, no. 19, p. 3028, 23 September. 2023.

VI. GARBERN, JC; QUIAT, D. Cardiomyopathies. In: Nadas' Pediatric Cardiology . 3rd ed. [sl] Elsevier, 2025. p. 592–606.

VII. GELEN, V.; ŞENGÜL, E.; KÜKÜRT, A. Thyroid Hormones (T3 and T4) and Their Effects on the Cardiovascular System. In: Hyperthyroidism - Recent Updates . [sl] IntechOpen, 2023. p. 1–12.

VIII. GENCER, B.; CAPPOLA, AR; RODONDI, N.; COLLET, T.-H. Challenges in the Management of Atrial Fibrillation With Subclinical Hyperthyroidism. Frontiers in Endocrinology , vol. 12, p. 795492, 4 Jan. 2022.

IX. KOSTOPOULOS, G.; EFFRAIMIDIS, G. Epidemiology, prognosis, and challenges in the management of hyperthyroidism-related atrial fibrillation. European Thyroid Journal , vol. 13, no. 2, 20 Feb. 2024.

X. KUMARI, Y.; BAI, P.; WAQAR, F.; ASIF, AT; IRSHAD, B.; RAJ, S.; VARAGANTIWAR, V.; KUMAR, M.; NEHA, F.; CHAND, S.; KUMAR, S.; VARRASSI, G.; KHATRI, M.; MOHAMAD, T. Advancements in the Management of Endocrine System Disorders and Arrhythmias: A Comprehensive Narrative Review. Cureus , vol. 15, no. 10, p. e46484, 4 Oct. 2023.

XI. LISCO, G.; GIAGULLI, VA; IOVINO, M.; ZUPO, R.; GUASTAMACCHIA, E.; DE PERGOLA, G.; IACOVIELLO, M.; TRIGGIANI, V. Endocrine system dysfunction and chronic heart failure: a clinical perspective. Endocrine , vol. 75, no. 2, p. 360–376, 28 Feb. 2022.

XII. NAVARRO-NAVAJAS, A.; CRUZ, JD; ARIZA-ORDOÑEZ, N.; GIRAL, H.; PALMEZANO, J.; BOLÍVAR-MEJÍA, A.; SANTANA, Q.; FERNANDEZ, R.; DURANGO, L.; SALDARRIAGA, C.; MATEUS, JC; GARNICA, D.; SARTA-GARCÍA, JG; LIZCANO, F.; TAPIAS, CA Cardiac manifestations in hyperthyroidism. Reviews in Cardiovascular Medicine , vol. 23, no. 4, p. 136, 11 April. 2022.

XIII. OLANREWAJU, OA; ASGHAR, R.; MAKWANA, S.; YAHYA, M.; KUMAR, N.; KHAWAR, M.H.; AHMED, A.; ISLAM, T.; KUMARI, K.; SHADMANI, S.; ALI, M.; KUMAR, S.; KHATRI, M.; VARRASSI, G.; MOHAMAD, T. Thyroid and Its Ripple Effect: Impact on Cardiac Structure, Function, and Outcomes. Cureus , vol. 16, no. 1, p. e51574, Jan. 2024.

XIV. PASCHOU, SA; BLETSA, E.; STAMPOULOGLOU, PK; TSIGKOU, V.; VALATSOU, A.; STEFANAKI, K.; KAZAKOU, P.; SPARTALIS, M.; SPARTALIS, E.; OIKONOMOU, E.; SIASOS, G. Thyroid disorders and cardiovascular manifestations: an update. Endocrine , vol. 75, no. 3, p. 672–683, 15 Mar. 2022.

XV. RASOOL, R.; UNAR, A.; JAFAR, TH; CHANIHOON, GQ; MUBEEN, B. A Role of Thyroid Hormones in Acute Myocardial Infarction: An Update. Current Cardiology Reviews , vol. 19, no. 1, Jan. 2023.

XVI. STUDEN, KB; GABERSCEK, S.; ZALETEL, K.; BLINC, A.; SABOVIC, M.; SCHERNTHANER, G.-H.; ANAGNOSTIS, P.; ANTIGNANI, PL; JENSTERLE, M.; MIKHAILIDIS, DP; POREDOS, P. Thyroid Disorders and Peripheral Arterial Disease. Current Vascular Pharmacology , vol. 22, no. 1, p. 36–40, Jan. 2024.

XVII. SZWARCBARD, N.; TOPLISS, DJ Hypertension in thyroid disease and primary hyperparathyroidism. In: PAPPACHAN, JM. CJF (Ed.). . Endocrine Hypertension . Manchester: Elsevier, 2023. p. 249–261.

XVIII. VYAS, J.; RAYTTHATHA, N.; PRAJAPATI, B. Endothelial Dysfunction and Its Related Disorders. In: Current Trends in the Diagnosis and Management of Metabolic Disorders . 1st ed. Boca Raton: CRC Press, 2024. p. 305–320.

XIX. WATANABE, M.; OHASHI, H.; SEGAWA, T.; OGASAWARA, M.; HASEGAWA, A.; INOUE, S. Cardiovascular Symptoms. In: CHIBA, T.; YAMADA, H. (Eds.). . Internal Medicine for Dental Treatments . Singapore: Springer Nature Singapore, 2023. p. 13–23.

XX. YAMAKAWA, H.; KATO, T.S.; NOH, JY; YUASA, S.; KAWAMURA, A.; FUKUDA, K.; AIZAWA, Y. Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside. Frontiers in Physiology , vol. 12, p. 606931, 18 Oct. 2021.

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