The Negative Impact of Vaping and Electric Cigarettes for Healing of Chronic Wounds: A Literature Review

Main Article Content

Amir Subhan
Ahmad Fawzy

Abstract

Non-smokers, particularly adolescents, face significant public health risks from e-cigarette use due to immediate health hazards, the potential for initiating tobacco use, and insufficient data on critical health outcomes, including wound healing. This study investigates vaping's impact on chronic wound healing, emphasizing e-cigarette chemical components. E-cigarettes contain common constituents: 1) Base liquids: Propylene glycol (PG) and vegetable glycerin (VG), 2) Nicotine, 3) Flavoring chemicals and additives, 4) Trace contaminants and toxins. Chronic wounds exhibit persistent inflammation, impaired proliferation, delayed remodeling, and environmental factors (e.g., ischemia, infection, trauma). E-cigarette components impair wound healing: VG induces osmotic effects and cellular toxicity, nicotine causes vasoconstriction, reduced oxygenation, and impaired angiogenesis. Flavoring chemicals contribute to cytotoxicity and modulate inflammatory responses, while contaminants like heavy metals induce oxidative stress and inflammation. Despite e-cigarettes' lower harm compared to traditional cigarettes, their effects on chronic wound healing remain poorly understood. Further research is essential to elucidate smoking's precise impact on chronic wound healing.

Article Details

How to Cite
Subhan, A., & Ahmad Fawzy. (2024). The Negative Impact of Vaping and Electric Cigarettes for Healing of Chronic Wounds: A Literature Review. International Journal of Medical Science and Clinical Research Studies, 4(05), 925–930. https://doi.org/10.47191/ijmscrs/v4-i05-25
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Articles

References

I. Han, G. Ceilley, R. Chronic Wound Healing: A Review of Current Management and Treatments. 2017. Advances in Therapy 34(3): 599–610. DOI 10.1007/s12325-017-0478-

II. II.Banks, E., Yazidjoglou, A., Brown, S., Nguyen, M., Martin, M., Beckwith, K., Daluwatta, A., Campbell, S., & Joshy, G Electronic cigarettes and Health Outcomes: Umbrella and systematic review of the global evidence. 2023. Medical Journal of Australia, 218(6), 267–275.

https://doi.org/10.5694/mja2.51890

III. III.Thieman, T., Westmark, D., & Sutton, A. Electronic cigarettes and Cutaneous Wound Healing: A systematic review. 2023. Journal of the American Academy of Dermatology, 88(4), 911–912. https://doi.org/10.1016/j.jaad.2022.10.042

IV. IV.Kalkhoran S, Benowitz NL, Rigotti NA. Prevention and treatment of tobacco use. Journal of the American College of Cardiology. 2018 Aug;72(9):1030–45. doi:10.1016/j.jacc.2018.06.036

V. V.Yasser, H. Joshua, V. Peter, D. Amanda, M. Wound Healing: A Comprehensive Review 2021

VI. Semin Plast Surg 35(3): 141–144 doi: 10.1055/s-0041-1731791

VII. VI.Zhu S;Yu Y;Ren Y;Xu L;Wang H;Ling X;Jin L;Hu Y;Zhang H;Miao C;Guo K; The emerging roles of neutrophil extracellular traps in wound healing Cell Death and Disease 22:12(11):984 2021 doi: 10.1038/s41419-021-04294-3.

VIII. VII.Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: Molecular and cellular mechanisms. Journal of Investigative Dermatology. 2007 127(3):514–25. doi:10.1038/sj.jid.5700701

IX. VIII.Bowler, J. Acute and chronic wound infections: microbiological, immunological, clinical and therapeutic distinctions Journal of Wound Care 31(5) https://doi.org/10.12968/jowc.2022.31.5.436

X. IX.Levine, J.Pressure Injury and Chronic Wounds. (eds) Geriatric Medicine.2023.

https://doi.org/10.1007/978-3-030-01782-8_91-1

XI. X.Kim, M.D., Chung, S., Baumlin, N.. The combination of propylene glycol and vegetable glycerin e-cigarette aerosols induces airway inflammation and mucus hyperconcentration. 2024. Sci Rep 14:1942 . https://doi.org/10.1038/s41598-024-52317-8

XII. XI.Davies, C. S., & Ismail, A. Nicotine has deleterious effects on wound healing through increased vasoconstriction. 2016. BMJ, i2709 https://doi.org/10.1136/bmj.i2709

XIII. XII.Bonner, E., Chang, Y., Christie, E., Colvin, V., Cunningham, B., Elson, D., Ghetu, C., Huizenga, J., Hutton, S. J., Kolluri, S. K., Maggio, S., Moran, I., Parker, B., Rericha, Y., Rivera, B. N., Samon, S., Schwichtenberg, T., Shankar, P., Simonich, M. T., … Tanguay, R. L. The chemistry and toxicology of Vaping. 2021. Pharmacology & Therapeutics, 225, 107837. https://doi.org/10.1016/j.pharmthera.2021.107837

XIV. XIII.Gray, N., Halstead, M., Gonzalez-Jimenez, N., Valentin-Blasini, L., Watson, C., & Pappas, R. S. Analysis of toxic metals in liquid from electronic cigarettes. 2019. International Journal of Environmental Research and Public Health, 16(22), 4450. https://doi.org/10.3390/ijerph16224450

XV. XIV.Ashour, O., Al-Huneidy, L., & Noordeen, H. The implications of vaping on surgical wound healing: A systematic review. 2023. Surgery, 173(6), 1452–1462.

https://doi.org/10.1016/j.surg.2023.02.017

XVI. XV.Cai H, Garcia JGN, Wang C. More to add to e-cigarette regulations. Chest. 2020 Apr;157(4):771–3. doi:10.1016/j.chest.2019.11.024

XVII. XVI.Park-Lee E, Ren C, Sawdey MD, Gentzke AS, Cornelius M, Jamal A, et al. notes from the field: e-cigarette use among middle and high school students — National Youth Tobacco Survey, United States, 2021. MMWR Morbidity and Mortality Weekly Report. 2021 Oct 1;70(39):1387–9. doi:10.15585/mmwr.mm7039a4

XVIII. XVII.Fracol M, Dorfman R, Janes L, Kulkarni S, Bethke K, Hansen N, et al. The surgical impact of e-cigarettes: A case report and review of the current literature. Archives of Plastic Surgery. 2017 Nov;44(06):477–81. doi:10.5999/aps.2017.00087

XIX. XVIII.Rinker B. The evils of nicotine. Annals of Plastic Surgery. 2013 May;70(5):599–605. doi:10.1097/sap.0b013e3182764fcd

XX. XIX.Ahn C, Mulligan P, Salcido R “Sal.” Smoking-the bane of wound healing. Advances in Skin & Wound Care. 2008 May;12(5):227–36. doi:10.1097/01.asw.0000305440.62402.43

XXI. XX.Sørensen LT, Jørgensen S, Petersen LJ, Hemmingsen U, Bülow J, Loft S, et al. Acute effects of nicotine and smoking on blood flow, tissue oxygen, and aerobe metabolism of the skin and subcutis. Journal of Surgical Research. 2009 Apr;152(2):224–30. doi:10.1016/j.jss.2008.02.066

XXII. XXI.Abbas SM, Hill AG. Smoking is a major risk factor for wound dehiscence after midline abdominal incision; case–control study. ANZ Journal of Surgery. 2009 Apr;79(4):247–50. doi:10.1111/j.1445-2197.2009.04854.x

XXIII. XXII.McDaniel JC. Smoking, chronic wound healing, and implications for evidence-based practice. Journal of Wound, Ostomy & Continence Nursing. 2014 Sept;41(5). doi:10.1097/won.0000000000000077

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