Advancements in Topical and Systemic Antibiotic Management for Burn Wounds: A Comprehensive Literature Review

Main Article Content

Rara Nafi Agripina
Ahmad Fawzy

Abstract

Introduction: Antimicrobial treatment in burn patient include systemic and topical antibiotic care should be carefully deliberated to prevent the development of resistant organisms


Methods: This literature review was compiled using information from numerous open access web databases. Data were compiled and analyzed.


Results and Discussions: To prevent antibiotic resistance and prevent infection, the best prophylactic antibiotics for burn patients are topical antibiotics. However, for the treatment of patients with extensive burns or those with antibiotic resistance, especially antibiotics for gram-positive bacteria, systemic antibiotics can be used for treatment.


Conclusion: The use of antibiotics in patients with burns can be adjusted to the patient's needs. surgeons may consider its use to prevent antibiotic resistance in patients.

Article Details

How to Cite
Agripina, R. N., & Ahmad Fawzy. (2024). Advancements in Topical and Systemic Antibiotic Management for Burn Wounds: A Comprehensive Literature Review. International Journal of Medical Science and Clinical Research Studies, 4(05), 946–952. https://doi.org/10.47191/ijmscrs/v4-i05-28
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Articles

References

I. Żwierełło W, Piorun K, Skórka-Majewicz M, Maruszewska A, Antoniewski J, Gutowska I. Burns: Classification, Pathophysiology, and Treatment: A Review. Int J Mol Sci. 2023 Feb 13;24(4):3749.

II. Markiewicz-Gospodarek A, Kozioł M, Tobiasz M, Baj J, Radzikowska-Büchner E, Przekora A. Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice. Int J Environ Res Public Health. 2022 Jan 25;19(3):1338.

III. Mir MA, Khurram MF, Khan AH. What should be the antibiotic prescription protocol for burn patients admitted in the department of burns, plastic and reconstructive surgery. Int Wound J. 2017 Feb;14(1):194-7.

IV. Nímia HH, Carvalho VF, Isaac C, Souza FÁ, Gemperli R, Paggiaro AO. Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis. Burns. 2019 Mar;45(2):282-92.

V. Hajská M, Slobodníková L, Hupková H, Koller J. In vitro efficacy of various topical antimicrobial agents in different time periods from contamination to application against 6 multidrug-resistant bacterial strains isolated from burn patients. Burns. 2014 Jun;40(4):713-8.

VI. Kempf M, Kimble RM, Cuttle L. Cytotoxicity testing of burn wound dressings, ointments and creams: a method using polycarbonate cell culture inserts on a cell culture system. Burns. 2011 Sep;37(6):994-1000.

VII. Yousefi M, Dadashpour M, Hejazi M, Hasanzadeh M, Behnam B, de la Guardia M, Shadjou N, Mokhtarzadeh A. Anti-bacterial activity of graphene oxide as a new weapon nanomaterial to combat multidrug-resistance bacteria. Mater Sci Eng C Mater Biol Appl. 2017 May 1;74:568-581.

VIII. Gómez-Núñez MF, Castillo-López M, Sevilla-Castillo F, Roque-Reyes OJ, Romero-Lechuga F, Medina-Santos DI, Martínez-Daniel R, Peón AN. Nanoparticle-Based Devices in the Control of Antibiotic Resistant Bacteria. Front Microbiol. 2020 Nov 25;11:563821.

IX. Yilmaz AC, Aygin D. Honey dressing in wound treatment: A systematic review. Complement Ther Med. 2020 Jun;51:102388.

X. Javia A, Amrutiya J, Lalani R, Patel V, Bhatt P, Misra A. Antimicrobial peptide delivery: an emerging therapeutic for the treatment of burn and wounds. Ther Deliv. 2018 May;9(5):375-86.

XI. Lei J, Sun L, Huang S, Zhu C, Li P, He J, Mackey V, Coy DH, He Q. The antimicrobial peptides and their potential clinical applications. Am J Transl Res. 2019 Jul 15;11(7):3919-31.

XII. Ray P, Singh S, Gupta S. Topical antimicrobial therapy: Current status and challenges. Indian J Med Microbiol. 2019 Jul-Sep;37(3):299-308.

XIII. Nair A, Jacob S, Al Dhubiab B, Attimarad M, Harsha S. Basic considerations in the dermatokinetics of topical formulations. Brazilian J Pharm Sci 2013;49:423-34.

XIV. Lavrentieva A, Kontou P, Soulountsi V, Kioumis J, Chrysou O, Bitzani M. Implementation of a procalcitonin-guided algorithm for antibiotic therapy in the burn intensive care unit. Ann Burns Fire Disasters. 2015 Sep 30;28(3):163-70.

XV. Kirby JP, Mazuski JE. Prevention of surgical site infection. Surg Clin North Am. 2009 Apr;89(2):365-89, viii.

XVI. Ozbek S, Ozgenel Y, Etöz A, Akin S, Kahveci R, Heper Y, Ercan I, Ozcan M. The effect of delayed admission in burn centers on wound contamination and infection rates. Ulus Travma Acil Cerrahi Derg. 2005 Jul;11(3):230-7.

XVII. Wilkinson RE, Hill DM, Hickerson WL. Outcome analysis of colistin-treated burn center patients. Burns. 2017 Sep;43(6):1244-9.

XVIII. Vinaik R, Barayan D, Shahrokhi S, Jeschke MG. Management and prevention of drug resistant infections in burn patients. Expert Rev Anti Infect Ther. 2019 Aug;17(8):607-19.

XIX. Hashemian SMR, Farhadi T, Ganjparvar M. Linezolid: a review of its properties, function, and use in critical care. Drug Des Devel Ther. 2018 Jun 18;12:1759-67.

XX. Rizzetto G, Molinelli E, Radi G, Diotallevi F, Cirioni O, Brescini L, Giacometti A, Offidani A, Simonetti O. Role of Daptomycin in Cutaneous Wound Healing: A Narrative Review. Antibiotics (Basel). 2022 Jul 14;11(7):944.

XXI. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010 May;31(5): 431-55.

XXII. McKinnon PS, Davis SL. Pharmacokinetic and pharmacodynamic issues in the treatment of bacterial infectious diseases. Eur J Clin Microbiol Infect Dis. 2004 Apr;23(4):271-88.

XXIII. Blanchet B, Jullien V, Vinsonneau C, Tod M. Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients. Clin Pharmacokinet. 2008;47(10):635-54.

XXIV. Wood GC, Chapman JL, Boucher BA, et al. Tobramycin bladder irrigation for treating a urinary tract infection in a critically ill patient. The Annals of Pharmacotherapy. 2004 Jul-Aug;38(7-8):1318-9.

XXV. Hill DM, Scott ES, William LH. Rational selection and use of antimicrobials in patients with burn injuries.Clin Plastic Surg. 2017;44(3): 521-4

XXVI. Doernberg SB, Abbo LM, Burdette SD, Fishman NO, Goodman EL, Kravitz GR, Leggett JE, Moehring RW, Newland JG, Robinson PA, Spivak ES, Tamma PD, Chambers HF. Essential Resources and Strategies for Antibiotic Stewardship Programs in the Acute Care Setting. Clin Infect Dis. 2018 Sep 28;67(8):1168-74.

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