Pharmacodynamic Mechanisms of the Development of Pulmonary Fibrosis Due to Amiodarone use

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Vania Barbara Escobedo Sandoval
Saulo Emmanuel Gomez de Alba
Mildred Andrea Zuñiga Onofre
Regina De La Garza Torres
Leonardo Ramirez Nucamendi
Miguel Duran Vera

Abstract

Introduction: Amiodarone is a benzofuran derivative with highly effective class III antidysrhythmic activity used in ventricular and supraventricular arrhythmia; however, its most side effect is pulmonary toxicity, with an incidence of 0 to 10%, and a mortality of 1 to 33%. The mechanism of the adverse reaction is still a matter of investigation. Therefore, the overall objective of this study is to determine the time in which pulmonary fibrosis develops from the use of amiodarone, which we hope to obtain with the following research question: What is the time in which pulmonary fibrosis develops from the use of amiodarone?


Discussion: based on the sources reviewed, these establish that there is a risk of developing pulmonary adverse reactions from the therapeutic use of amiodarone directly related to the serum concentrations of the drug, but complete these data with broader populations.


Conclusions: We were able to determine from the literature review that lung injury can be activated by low and high therapeutic doses of amiodarone.

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How to Cite
Vania Barbara Escobedo Sandoval, Saulo Emmanuel Gomez de Alba, Mildred Andrea Zuñiga Onofre, Regina De La Garza Torres, Leonardo Ramirez Nucamendi, & Miguel Duran Vera. (2023). Pharmacodynamic Mechanisms of the Development of Pulmonary Fibrosis Due to Amiodarone use. International Journal of Medical Science and Clinical Research Studies, 3(10), 2292–2296. https://doi.org/10.47191/ijmscrs/v3-i10-35
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