Antimicrobial and Anti-Inflammatory Properties of Silver Nanoparticles in Burn Treatment
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Abstract
Burn is one of the most common injuries which leading to high morbidity and mortality. Inflammation and infection involve in burn pathophysiology. Inflammation occurs in burn mainly due to release of inflammatory cytokines, while infection occurs when skin barrier damage and immune system is compromised due to suppression of neutrophils and T cells. In previous studies, silver nanoparticles (AgNPs) exhibit antimicrobial and anti-inflammatory properties through several mechanism. Antimicrobial mechanism of AgNPs including the damage of cell wall and alteration inner part of cell, while anti-inflammatory mechanism of AgNPs is by reducing pro-inflammatory cytokines. Therefore, silver nanoparticles can be reasonable treatment for burn.
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References
I. Yakupu et al. The epidemiological characteristic and trends of burns globally. BMC Public Health (2022) 22:1596
II. Pratama AM, Lewa A. The Protective Role of Strong Antioxidant Astaxanthin on Burn Wound and Burn-Induced Early Acute Kidney Injury through Abilities to Relieve Oxidative Stress and Inhibit Apoptosis by Modulating Mitochondrial-Apoptotic Pathways. IJMSCRS 2022, 2, 1591-1595
III. I. Kaddoura, G. Abu-Sittah, A. Ibrahim, R. Karamanoukian, N. Papazian. Burn injury: review of pathophysiology and therapeutic modalities in major burns. Ann Burns Fire Disasters. 2017 Jun 30; 30(2): 95–102
IV. Aziz Z, Hassan BA. The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials. Burns Volume 43, Issue 1, February 2017, Pages 50-57
V. Bruna T, Bravo FM, Jara P, Caro N. Silver Nanoparticles and Their Antibacterial Applications. Int. J. Mol. Sci. 2021, 22, 7202
VI. Rybka M, Mazurek L, Konop M. Beneficial Effect of Wound Dressings Containing Silver and Silver Nanoparticles in Wound Healing— From Experimental Studies to Clinical Practice. Life 2023, 13(1), 69
VII. Jeschke MG, et al. Burn injury. Nat Rev Dis Primers. 2020; 6(1): 11
VIII. Sierawska O, et al. Innate Immune System Response to Burn Damage— Focus on Cytokine Alteration. Int. J. Mol. Sci. 2022, 23, 716
IX. Mulder PP, et al. Persistent Systemic Inflammation in Patients with Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles. Front. Immunol., 29 January 2021
X. Lang TC, et al. A Critical Update of the Assessment and Acute Management of Patients with Severe Burns. Adv Wound Care. 2019 Dec 1; 8(12): 607–633
XI. Kelly EJ, Oliver MA, Carney BC, Shupp JW. Infection and Burn Injury. Eur. Burn J. 2022, 3(1), 165-179
XII. Tsolakidis S. Infections in Burn Patients: A Retrospective View over Seven Years. Medicina 2022, 58(8), 1066
XIII. Mikhailova EO. Silver Nanoparticles: Mechanism of Action and Probable Bio-Application. J. Funct. Biomater. 2020, 11, 84
XIV. Dakal TC. Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles. Front. Microbiol, 16 November 2016 Sec. Antimicrobials, Resistance and Chemotherapy Volume 7 – 2016
XV. Ahmad SA, et al. Bactericidal activity of silver nanoparticles: A mechanistic review. Materials Science for Energy Technologies 3 (2020) 756–769
XVI. Wu B, Zhang F, Jiang W, and Zhao A. Nanosilver Dressing in Treating Deep II Degree Burn Wound Infection in Patients with Clinical Studies. Comput Math Methods Med. 2021; 2021
XVII. Jahromi MA, et al. Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing. Adv Drug Deliv Rev. 2018 January 01; 123: 33–64
XVIII. Rigo C, et al. Active Silver Nanoparticles for Wound Healing. Int. J. Mol. Sci. 2013, 14, 4817-4840