Female Patient with Ceftriaxone-Induced Drug Eruption with Eosinophilia and Systemic Symptoms in Second Level Care. Case Report
Main Article Content
Abstract
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction. Therefore, the case of a 51-year-old woman with no history of drug allergies is presented. In empirical treatment with Ceftriaxone, presenting 15 days later pruritic maculopapular rash on the chest, abdomen and extremities accompanied by temperature rises of up to 39°C. Laboratories with leukocytes of 47.38/uL, with eosinophils of 27.07/uL, and skin biopsy report with inflammatory infiltrate in the dermis at the expense of eosinophils. regiSCAR and J-SCAR with results of 8 and 6 points respectively. Administering methylprednisolone 250 mg every 24 hours for 3 days, continuing with prednisone 50 mg per day. Improvement of skin lesions and laboratory abnormalities at 72 hours. DRESS induced by this antibiotic is rare. Appropriate assessment of the indications and diagnostic assumption of side effects is important because the manifestations are potentially reversible.of rash, fever, facial edema, lymphadenopathy, hematologic abnormalities, and visceral involvement.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
I. Stirton H, Shear NH, Gad RPD. Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS)/Drug-Induced Hypersensitivity Syndrome (DiHS)—Readdressing the DReSS. Biomedicines 2022, 10, 999.
II. Shiohara T, Mizukawa Y. Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019. Allergology International 68 (2019) 301-308.
III. NamY.H,ParkMR,NamHJ,LeeSK,KimKH, et al. Drug reaction with eosinophilia and systemic symptoms syndrome is not uncommon and shows better clinical outcome than generally recognized. Allergol Immunopathol (Madr). 2 01 5; 43 (1) :1 9- 2 4.
IV. Sharifzadeh S, Mohammadpour AH, Tavanae A, Elyasi S. Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review. European Journal of Clinical Pharmacology (2021) 77:275–289.
V. Da silva SA, Figuereido MP, Neto LC, Reiis DB, Damásio MS. Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome). Rev assoc med BRas 2016; 62(3):227-230.
VI. Cardones AR. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Clinics in Dermatology (2020) 38, 702–711.
VII. Agrawal A, Ravindu, Kannauje P. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by ceftriaxone with successful treatment — A case report and literature review. ndian Journal of Pharmacy and Pharmacology 2021;8(4):298–300.
VIII. Cho YT, Yang CW, Chu CY. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System. Int. J. Mol. Sci. 2017, 18, 1243.
IX. Scrace B, Fityan A, Bigham C. Drug reactions with eosinophilia and systemic symptoms. BJA Education, 20(2): 65e71 (2020).
X. Guleria VS, Dhillon M, Gill S, Naithani N. Ceftriaxone induced drug rash with eosinophilia and systemic symptoms. J Res Pharm Pract 2014;3:72‐4.
XI. Husain Z, Reddy BY, Schwartz RA. DRESS syndrome. J AM ACAD DERMATOL MAY 2013. VOLUME 68, NUMBER 5.
XII. Criado PR, Jardim CRF, Avancini MJ, Giuli SC, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) / Drug-Induced Hypersensitivity Syndrome (DIHS): An Bras Dermatol. 2012;87(3):435-49.