The Current Art Combination of Platelet-Rich Plasma and Poly-D,L-Lactic Acid For Improvement of Deep Nasolabial Folds: A Case Report

Main Article Content

Andi Muh. Octavian Pratama
Anwar Lewa

Abstract

ABSTRACT


Background: Platelet-rich plasma (PRP) is blood plasma containing an above baseline level of platelets and growth factors. Recently, Platelet-rich plasma (PRP) has come to the attention of aesthetic surgeons, with burgeoning new applications ranging from hair restoration to soft tissue augmentation. Injectable Poly-D,L-Lactic Acid (PDLLA) is a biostimulator rather than a traditional filler, which provides immediate volumetric improvement. Injectable PLA can produce a result comparable with Hyaluronic Acid fillers for the correction of wrinkles such as nasolabial folds, and can be a good choice for such a treatment.


Methods: A Female 45 years Old with deep smile lines and fine wrinkles on cheeks. The patient was treated with injected of Poly(D,L Lactic Acid) and Platelet Rich Plasma. Poly-D,L-Lactic Acid was injected subdermal with retrograde linear thread technique and used 24-G cannula needle. After 3 weeks PDLLA Injection, PRP was injected intradermal into the whole face especially along the smile lines using a 32-G Needle at a dose of 0.05 ml at each injection site with a distance of about 0.5-1.0 cm. PRP was injected every 2 weeks for 3 months.


Results: Wrinkle Severity Rating Scale was downgrading and skin quality like skin tone looks more brightening and fading hyperpigmentation.


Conclusion: The combination of Poly-D,L-Lactic Acid and Platelet-Rich Plasma is effective for facial rejuvenation.


Keywords: Platelet-rich plasma (PRP), Poly-D,L-Lactic Acid, Nasolabial Folds, Wrinkle Severity Rating Scale

Article Details

How to Cite
Pratama, A. M. O., & Anwar Lewa. (2022). The Current Art Combination of Platelet-Rich Plasma and Poly-D,L-Lactic Acid For Improvement of Deep Nasolabial Folds: A Case Report. International Journal of Medical Science and Clinical Research Studies, 2(10), 1078–1081. https://doi.org/10.47191/ijmscrs/v2-i10-11
Section
Articles

References

I. No, Y. A., Seok, J., Hyun, M. Y., Kwon, T.-R., Oh, C. T., Choi, E. J., & Kim, B. J. (2015). Long-Term (24-Month) Safety Evaluation of Poly-DL-Lactic Acid Filler Injection for the Nasolabial Fold. Plastic and Reconstructive Surgery, 135(6), 1074e–1075e. doi:10.1097/prs.0000000000001247

II. Choi, Y.-J., Kim, H.-S., Min, J. H., Nam, J.-H., Lee, G.-Y., & Kim, W.-S. (2017). A clinical study on the usefulness of autologous plasma filler in the treatment of nasolabial fold wrinkles. Journal of Cosmetic and Laser Therapy, 19(3), 174–180. doi:10.1080/14764172.2016.1248443

III. Jui-Yu Lin and Chuan-Yuan Lin. Injectable Poly-D, L-lactic Acid in Facial Rejuvenation: Three Case Reports. Cosmetol J 2020, 4(1): 000120

IV. Lin CY, Lin JY, Yang DY, Lee SH, Kim JY, et al. (2019) Efficacy and safety of poly-D,L-lactic acid microspheres as subdermal fillers in animals. Plast Aesthet Res 6: 16.

V. Hyun MY, Lee Y, No YA, Yoo KH, Kim MN, et al. (2015) Efficacy and safety of injection with poly-L-lactic acid compared with hyaluronic acid for correction of nasolabial fold: A randomized, evaluator blinded, comparative study. Clin Exp Dermatol 40(2): 129-135.

VI. Banihashemi M, Zabolinejad N, Salehi M, Hamidi Alamdari D, Nakhaizadeh S. Platelet-rich Plasma use for facial rejuvenation: a clinical trial and review of current literature. Acta Biomed. 2021;92(2):e2021187. Published 2021 May 12. doi:10.23750/abm.v92i2.9687

VII. Noha N. Doghim, et al. Assessment of Efficacy of Platelet-Rich Plasma Injection for Facial Rejuvenation. Med. J. Cairo Univ., Vol. 87, No. 3, June: 1371-1376, 2019

VIII. Man,D et all. The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plast. Reconstruct. Surg., 107 (1): 229- 37: 25-33

IX. Day, D.J., et al. The Wrinkle Severity Rating Scale: A Validation Study. American Journal of Clinical Dermatology, 5, 49-52.

Most read articles by the same author(s)