Effect of Papaya Leaf Extract (Carica Papaya L.) on Two-Hour Postprandial Blood Glucose in Male Wistar Rats (Rattus Norvegicus) Induced by Streptozotocin and Nicotinamide
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Abstract
Diabetes mellitus (DM) is a metabolic disease that involves inappropriately elevated blood glucose levels. Suspicion of diabetes mellitus can be done by checking two hours postprandial blood glucose. Glimepiride is a drug used in the treatment of diabetes mellitus that belongs to the sulfonylurea group. However, like other sulfonylureas, the administration of glimepiride in patients with diabetes mellitus can trigger side effects in the form of hypoglycaemia due to increased insulin secretion. One of the plants that can be utilized as an antidiabetic drug is papaya leaf. Research in the form of experimental Randomized Controlled Trial (RCT) with Pretest-Posttest Only Group Design research design using male wistar strain white rats for 38 days, with 35 rats. The administration of papaya leaf extract at a dose of 150mg/kg and 200mg/kg in group IV and V rats is proven to have the small effect of lowering two hours postprandial blood glucose in male Wistar rats. In conclusion depend on the dose the administration of papaya leaf had a small effect in changing two-hours postprandial blood glucose.
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