Mesenchymal Hamartoma Liver Showing Malignant Transformation to Undifferentiated Embryonal Sarcoma- A Case Report

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Published: May 2, 2022
DOI: https://doi.org/10.47191/ijmscrs/v2-i5-02
Keywords:
Mesenchymal hamartoma Undifferentiated embryonal sarcoma

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Dr. Veena Vijayan
Junior resident, Department of Pathology, Government Medical College, Thiruvananthapuram, Kerala, India
Dr. Priya V S
Assistant professor, Department of Pathology, Government Medical College, Thiruvananthapuram, Kerala, India
Dr. Lilarani Vijayaraghavan
Professor and Head of the Department, Department of Pathology, Government Medical College, Thiruvananthapuram, Kerala, India

Abstract

Mesenchymal hamartoma of liver is the third most common hepatic tumor in pediatric age group. Typically, it presents as a large multicystic mass in children. Gradually they get increases in size and some can undergo incomplete spontaneous regression and very rarely, few have shown malignant transformation to undifferentiated(embryonal) sarcoma. Here, we report a 6 year old female child with no relevant personal and family history, who presented with abdominal distension and vomiting. Radiology revealed a multiloculated large cystic lesion in the right lobe of liver with a possibility of hemangioendothelioma on ultrasonography and CT abdomen was suggestive of mesenchymal hamartoma of liver. Following worsening of symptoms, partial excision and marsupialisation of the cyst was performed. Histologically, it was diagnosed as mesenchynal hamartoma with undifferentiated embryonal sarcomatous component and immunohistochemical confirmation done.

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How to Cite
Dr. Veena Vijayan, Dr. Priya V S, & Dr. Lilarani Vijayaraghavan. (2022). Mesenchymal Hamartoma Liver Showing Malignant Transformation to Undifferentiated Embryonal Sarcoma- A Case Report. International Journal of Medical Science and Clinical Research Studies, 2(5), 295–301. https://doi.org/10.47191/ijmscrs/v2-i5-02
Issue
Vol. 2 No. 5 (2022): Volume 02 Issue 05 May 2022
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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

References

I. Cahís Vela N, Loverdos Eseverri I, Beltrán Salazar VP, Brun Lozano N, Ferreres Piñas JC, Hernández CJR. Liver Mesenchymal Hamartoma. J Pediatr Surg Case Rep. 2021 May 1;68:101839.

II. Saeed O, Saxena R. Primary mesenchymal liver tumors of childhood. Semin Diagn Pathol. 2017 Mar;34(2):201–7.

III. Mesenchymal hamartoma of the liver - PMC [Internet]. [cited 2022 Apr 6]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930303/

IV. Edmondson HA. Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood. AMA J Dis Child. 1956 Feb; 91(2):168–86.

V. Mesenchymal Hamartoma of the Liver: Complete Excision Always Necessary [Internet]. [cited 2022 Apr 25]. Available from:

https://www.hindawi.com/journals/cris/2017/8314102/?msclkid=8f065b58c44011ec98046906870b44f5

VI. Chang HJ, Jin SY, Park C, Park YN, Jang JJ, Park CK, et al. Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms. J Korean Med Sci. 2006 Feb;21(1):63–8.

VII. 1397657062Mesenchymal_Hamartoma_of_Liver_A_Rare_Case_Report.pdf [Internet]. [cited 2022 Apr 21]. Available from:

https://www.ijmhs.net/articles/1397657062Mesenchymal_Hamartoma_of_Liver_A_Rare_Case_Report.pdf?msclkid=566bcfb8c0f511ecab4ad835148c1540

VIII. Lauwers GY, Grant LD, Donnelly WH, Meloni AM, Foss RM, Sanberg AA, et al. Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. Am J Surg Pathol. 1997 Oct 1;21(10):1248–54.

IX. Martins-Filho SN, Putra J. Hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a pathologic review. Hepatic Oncol. 7(2):HEP19.

X. Habibzadeh P, Ansari Asl M, Foroutan HR, Bahador A, Anbardar MH. Clinicopathological study of hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a single center study from Iran. Diagn Pathol. 2021 Jun 24;16(1):55.

XI. Putra J, Ornvold K. Undifferentiated embryonal sarcoma of the liver: a concise review. Arch Pathol Lab Med. 2015 Feb;139(2):269–73.