International Journal of Medical Science and Clinical Research Studies

Analysis of Differences in the Quality of Health Services in Inpatient and Outpatient Patients Participating in National Health Insurance at Toto Kabila Hospital

Moh. Ichsan A. Antu, Herlina Jusuf, Sylva Flora Ninta Tarigan — Mon, 03 Jun 2024 00:00:00 +0000

Health services are products in the form of services or goods produced by a producer, in this case, it can be a provider or health institution (Retnaningsih, 2013). The research formulation is whether there is a difference in the quality of health services for inpatients and outpatients participating in national health insurance at the Toto Kabila Regional General Hospital. This research aims to determine the differences in the level of quality of health services for inpatients and outpatients participating in national health insurance at the Toto Kabila Regional General Hospital. The sample in this study consisted of 48 inpatients and 48 outpatients at Toto Kabila Hospital. The results of data analysis showed significant differences in service quality based on service availability between inpatients and outpatients with a p-value = 0.004, namely ≤0.05. The difference in service quality based on service continuity is significant between inpatients and outpatients with a p-value = 0.000, namely ≤0.05. The difference in service quality based on medical support services is significant between inpatients and outpatients with a p-value = 0.000, namely ≤0.05.

The Effect of Consumption of Tila Fish Meatballs (Oreochromis Niloticus) on Increasing HB Levels in Ii Trimester Pregnant Women in the Telaga Jaya Health Center Area

Rima Melati Mohamad , Sunarto Kadir, Laksmyn Kadir — Mon, 03 Jun 2024 00:00:00 +0000

During pregnancy, the body needs more Iron than before pregnancy. Iron in pregnant women is required to form blood, red, fetus, and placenta. Formulation study: How Influence Consumption Freshwater Fish Meatballs to Increased HB Levels in Second Trimester Pregnant Women. Research purposes that know the influence of consumption of freshwater fish meatballs to enhancement HB levels in the Mother's second trimester of pregnancy. Types of research with use method experiment. Study This was conducted at the Telaga Jaya Health Center, Gorontalo Regency. Deep sample study This is a pregnant mother in the Telaga Jaya Community Health Center area, totaling 63 people, who used the method experiment. Results of bivariate data analysis There is an influence of Frequency consumption of Tilapia fish meatballs one time/ day, two times/ day, and three times/ day to improvement Hb levels in second-trimester pregnant women in the Telaga Jaya area with p-value = 0.00< α = 0.05, Yes influence of the level of compliance consumption Tilapia fish meatballs to improvement Hb levels in the mother second trimester pregnant in the Telaga Jaya Community Health Center area with p-value = 0.01 < α = 0.05 and exists influence before and after consume Tilapia fish meatballs to increased Hb in the mother second trimester of pregnancy with p-value = 0.00 < α = 0.05.

Development Studies on Treatment of Vomiting and Nausea: Bibliometrical Analysis from the Years 1946-2024

Ade Zayu Cempaka Sari, Andra Saferi Wijaya, Mercy Nafratilova — Wed, 05 Jun 2024 00:00:00 +0000

Nausea is the most common thing in pregnancy that is a symptom of discomfort that occurs in the early stages of pregnancies. This event has a considerable physical, social and psychological impact on women. The emotional and physical impact includes feelings of anxiety about the possibility of affecting the fetus. Research on the implementation of vomiting nausea in pregnancy found as many as 3030 articles, taken from the Pubmed database between 1875 and 2024. The purpose of the bibliometric analysis is to find out the research trends, the most widely used keywords, the journal of the most publishers, the author's instance and the country of collaboration of the author of the article. The keywords most commonly used by the authors are human, female, pregnancy, hyperemesis gravidarum, vomiting, nausea, treatment outcome. The American Journal of Obstetrics and Gynecology ranks first as the most widely published journal on Treatment vomiting and nausea, with a total of 144 articles. The highest affiliation of authors is from the University of Amsterdam and the Université de Californie, which have a total of 75 authors in common. The University of Toronto is in the next position with 64 authors, followed by the university of Cambridge with 70 authors. Multiple Country Publications (MCP) and Single Country Publication (SCP) collaborations are from the United States, China and Canada.

Evaluation of Analgesic Activity of Extract from Moringa Leaves (Moringa Oleifera Lamk) in Mice (Mus Musculus)

Thu, 06 Jun 2024 00:00:00 +0000

Every human being experiences pain such as during chronic pain, infection, surgery or other medical interventions. In overcoming pain in patients, it is necessary to administer drugs in the form of analgesics. One of the herbal plants that can be used is Moringa leaves (Moringa oleifera Lamk) which contains metabolite compounds such as flavonoids, alkaloids, steroids and tannins that have analgesic activity. The aim of this research is to assess the analgesic activity of Moringa leaf extract (Moringa oleifera Lamk) in mice (Mus musculus) using 96% ethanol solvent and writhing reflex method. The experimental animals were divided into 3 groups: negative control group (Na-CMC 0.5%), positive control group (aspirin) and treatment group (Moringa leaf extract). The treatment material is given orally. Animals were treated with 0.6% acetic acid injection intraperitoneally to give the effect of pain in mice. Measurement of the analgesic effect with the writhing reflex method is seen from the number of writhing. Based on the results of the study it can be concluded that the administration of Moringa leaf extract (Moringa oleifera Lamk) with the writhing reflex method has analgesic activity, which can reduce the pain response characterized by a decrease in the number of writhing in mice (Mus musculus).

Acute Respiratory Failure: Pathophysiology, Diagnosis, and Current Therapeutic Modalities

Thu, 06 Jun 2024 00:00:00 +0000

Acute respiratory failure (ARF) represents a critical condition wherein the respiratory system fails to maintain adequate gas exchange, leading to hypoxemia, hypercapnia, or both. The etiology of ARF is multifactorial, encompassing a wide array of pulmonary and extrapulmonary disorders. Prompt diagnosis and intervention are paramount to improving patient outcomes. This article provides a comprehensive review of the pathophysiology underlying ARF, diagnostic approaches, and the latest advancements in therapeutic strategies. We explore both invasive and non-invasive treatment modalities, including mechanical ventilation, extracorporeal membrane oxygenation (ECMO), pharmacotherapy, and supportive care measures. By integrating recent clinical evidence, we aim to elucidate the evolving landscape of ARF management, highlighting best practices and emerging innovations in the field.

The Description of Dental Caries in Children Aged 9 – 12-Years-Old at Rambipuji District Elementary School

Agus Sumono, Leni Rokhma Dewi (CA), Kiswaluyo, Dwi Prijatmoko — Thu, 06 Jun 2024 00:00:00 +0000

Background: Caries is the most common disease among various oral diseases and it still a major problem in developing countries impact on 60% -90% of school-age children and adults. The impact of caries that is not treated in children is toothache, and it caused reduction nutrition in children. Nutrition decrease affected in development of children. Objective: to describe dental caries in elementary school students in 9-12 years old in Rambipuji.

Method: The type of research used was descriptive observational study using cross-sectional data through elementary school students at Rambipuji in the period January 14-11 February 2019. Results: Caries is a top priority in school-age children up to adults.

Results: The results showed that female students used caries more than 55% and based on dental elements using caries, the mandibular first second molars improved caries more. Conclusion: female students have more caries difficulties. Distribution based on teeth published caries, first and second molars first caries more.

Evaluation of The Implementation of The Laboratory Information System Using the Hot Fit Method in Maxima Clinical Laboratory

Sadam Musawir, Sunarto Kadir, Teti Sutriyati Tuloli — Thu, 06 Jun 2024 00:00:00 +0000

Evaluation of information systems in the health domain goes beyond exclusively technological considerations but also includes evaluation of human and organizational dimensions. The information system evaluation model frequently health used is called HOT-Fit (Human Organization Technology-Fit). This model considers the complex interactions between human, organizational, and technological elements in the context of health information systems. This research aims to analyze the implementation of the Laboratory Information System using the HOT Fit method at the Maxima Clinical Laboratory. The research method used is quantitative with a cross-sectional research design using a survey approach. Research subjects include laboratory managers, laboratory staff, information system users, and patients. Primary data was collected through questionnaires and interviews, while secondary data was obtained from related documents. The data analysis technique used is descriptive analysis and Partial Least Square ( PLS ). The research results show that there is a significant influence between system quality (p-value = 0.041), information quality (p-value = 0.003), service quality (p-value = 0.003), and user satisfaction (p-value = 0.041). Research findings can be used as evaluation and improvement material for laboratory managers to increase the effectiveness and efficiency of health services by optimizing the use of information systems.

Analysis of Determinants of NCD Diabetes Mellitus in Tilango Health Centre

Hajar Hasan Ijonu, Sunarto Kadir, Sri Manovita Pateda — Thu, 06 Jun 2024 00:00:00 +0000

The incidence and prevalence of type 2 diabetes in adolescents varies according to ethnicity and other factors. Populations with a high incidence and prevalence of type 2 diabetes in young people also have a higher risk of developing type 2 diabetes in adults. This research aims to analyze the determinants of PTM Diabetes Mellitus at the Tilango Community Health Center. Analytical survey research method with a cross-sectional study design. The population is all Prolanis patients at the Tilango Community Health Center in 2023 totaling 104 people. Sampling used total sampling, so the total sample was 104 people. Analysis was carried out using the chi-square test and multiple logistic regression test. The research results of the multiple logistic regression test obtained the variables diet (0.016) and hypertension (0.003). The largest OR value was obtained for the diet variable (11.075). This research concludes that there is a relationship between diet, obesity, genetic history, hypertension, physical activity, and the incidence of PTM diabetes mellitus at the Tilango Health Center. Diet is the variable most related to the incidence of PTM Diabetes Mellitus at the Tilango Community Health Center, excessive eating patterns have an 11.075 times greater chance of developing diabetes mellitus.

Review of Cardiovascular Manifestations of Hyperthyroidism: Main Triggered Heart Diseases and Clinical Implications

Fri, 07 Jun 2024 00:00:00 +0000

Introduction: Hyperthyroidism, a common endocrinological condition characterized by excess production of thyroid hormones, has profound and varied effects on the cardiovascular system. The thyroid hormones, triiodothyronine (T3) and thyroxine (T4), play essential roles in regulating basal metabolism and cardiovascular function

Objective: To provide a comprehensive understanding of the various cardiac complications associated with hyperthyroidism and their clinical implications. Methods: This study constitutes a systematic review, classified as exploratory and descriptive. The preparation of the research was a bibliographical search in electronic databases on methods associated with RSL (Systematic Literature Review) and the applications of SMARTER (Simple Multi-Attribute Rating Technique using Exploiting Rankings).

Results: A comprehensive systematic search of the literature yielded a total of 5689 articles referring to the incidence of obesity and overweight in adolescents, of which 20 articles were eligible to be included in this systematic review.

Conclusion: Continuous research and therapeutic innovation play vital roles in the evolution of the treatment of hyperthyroidism and its cardiovascular complications. The development of personalized approaches that consider the genetic and clinical particularities of each patient can significantly improve quality of life and reduce associated morbidity and mortality.

Monogenic Obesity in Children: Current Perspectives and Clinical Implications

Fri, 07 Jun 2024 00:00:00 +0000

Introduction: Monogenic obesity is characterized by a mutation in a single gene, which directly influences metabolism, appetite control or other biological pathways associated with body weight regulation.

Objective: To provide practical insights for healthcare professionals working with affected children to improve health outcomes and quality of life.

Methods: This study constitutes a systematic review, classified as exploratory and descriptive. The preparation of the research was a bibliographical search in electronic databases on methods associated with RSL (Systematic Literature Review) and the applications of SMARTER (Simple Multi-Attribute Rating Technique using Exploiting Rankings).

Results: A comprehensive systematic search of the literature yielded a total of 4125 articles referring to the incidence of obesity and overweight in adolescents, of which 20 articles were eligible to be included in this systematic review.

Conclusion: With a continued and coordinated effort, it is possible to significantly improve health outcomes for these children, preparing them for a brighter future.

17-Year-Old Male with Electrical Conduction Burn, with Contact Area in Skull Treated with Orticochea-Type Flaps

Sat, 08 Jun 2024 00:00:00 +0000

The Orticochea flap, a multi-flap closure technique, is a recent addition to the field of reconstructive surgery. It is a safe and acceptable alternative for scalp reconstruction, as it can cover a skin and bone defect with local full-thickness skin, reducing the length of the procedure. The technique is particularly useful for rehabilitating cranium and frontal abnormalities, as it provides an appropriate blood supply and increases the surface area for closure. The orticochea flap is particularly suitable for significant frontal or vertex defects, no prior radiation exposure, and no hairline distortion.

Stevens Johnson Syndrome and Toxic Epidermal Necrolysis Updates on Management

Daniela Guerrero Carrillo — Sat, 08 Jun 2024 00:00:00 +0000

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are dermatologic emergencies characterized by extensive epidermal necrolysis and sloughing. The incidence rates vary depending on location, with the UK experiencing an annual incidence of 5.76 cases per million individuals from 1995 to 2013. Females are more frequently afflicted than males, with mortality rates ranging from 4.8-9% to 14.8-48%.

Nonpharmacologic treatment for SJS/TEN patients includes supportive care, fluid and electrolyte management, infection control, and wound care. The most critical component is the identification and cessation of the causative substance. Management of fluid, electrolytes, and nutrition is crucial for SJS/TEN patients, as they have lower fluid requirements than burn patients.

Prophylactic antibiotics do not enhance outcomes, but infection prevention requires appropriate wound care and antiseptic handling. The role of surgical debridement has been a topic of controversy, and the decision to pursue this treatment option depends on the location of care. Anti-shear therapy, which involves aspiration of blister fluid and preservation of denuded epidermis, has been shown to be effective in reducing mortality rates.

Pharmacologic treatment for SJS/TEN has been the subject of few prospective studies due to the disease's rarity. Various treatment regimens involving corticosteroids, IVIg, cyclosporine, and TNF-alpha inhibitors have been reported, but it is challenging to determine whether the disease's remission was due to a specific treatment or the natural course of the disease.

Stevens Johnson Syndrome Review

Daniela Guerrero Carrillo — Sat, 08 Jun 2024 00:00:00 +0000

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are dermatologic emergencies that are distinguished by extensive epidermal necrolysis and sloughing. The incidence rates are location-dependent. Mortality rates vary from 4.8-9% to 14.8-48%, with females being more frequently affected than males.

Supportive care, infection control, wound care, and fluid and electrolyte management comprise nonpharmacologic treatment for SJS/TEN patients. The identification and cessation of the causative substance are the most critical components. The management of fluid, electrolytes, and nutrition is essential for SJS/TEN patients, as they have lower fluid requirements than burn patients.

Prophylactic antibiotics do not improve outcomes; however, infection prevention necessitates appropriate wound care and antiseptic handling. The decision to pursue surgical debridement is contingent upon the location of care, and the function of this treatment option has been a subject of controversy. Anti-shear therapy, which entails the preservation of denuded epidermis and the aspiration of blister fluid, has been demonstrated to be effective in decreasing mortality rates.

The disease's rarity has resulted in a scarcity of prospective studies on pharmacologic treatment for SJS/TEN. There have been reports of a variety of treatment regimens that involve corticosteroids, IVIg, cyclosporine, and TNF-alpha inhibitors. However, it is difficult to ascertain whether the disease's remission was caused by a specific treatment or the natural course of the disease.

Studies have demonstrated that supportive care and cyclosporine have the potential to serve as alternative treatments for SJS/TEN. A meta-analysis of 10 studies revealed that patients who received cyclosporine had a survival advantage, while a meta-analysis of 67 studies revealed that the combination of corticosteroids and IVIg resulted in statistically significant improvements in outcomes. The severity of illness scores in patients with SJS/TEN overlap or TEN was reduced by plasmapheresis, which entails plasmapheresis and corticosteroids. In 86.8% of patients, TNF-alpha inhibitors have also demonstrated positive outcomes, despite their immunosuppressive properties. Nevertheless, the most effective pharmacological treatment for SJS/TEN must be determined by taking into account practical factors, such as cost. There is a lack of consensus regarding the most effective treatment, and additional research is required to ascertain the most effective treatment.

Lower Eyelid Reconstruction with Mustardé Flap

Sat, 08 Jun 2024 00:00:00 +0000

Restoring defects in the lower eyelids, particularly those that extend beyond two-thirds, can be challenging, especially after tumor resection. Basal cell carcinoma (BCC) is the most common form of skin cancer, affecting the lower eyelid and inner canthus. Grafts are often combined with flaps for replacing the posterior lamella or anterior lamella. The Mustardé rotational cheek flap is a popular choice for reconstructing the anterior lamella of the lower eyelid, as it meets the basic requirements of an ideal cutaneous flap. This wide-based pedicle flap can support free grafts needed to line the inside of the flap. Other autogenous grafts, such as labial mucosa, hard palate mucoperiosteum, auricular cartilage, and nasoseptal cartilage, have also been used in eyelid reconstruction. However, hard palate mucosa transplants provide uniformity and can be expensive. Hughes procedures are not suitable for individuals with amblyogenic age or one-seeking eyes. Combining a vascular flap with a superior graft like pericranium may provide a viable surgical option for enduring functional and aesthetic outcomes.

Mechanism of Isoniazid‐Induced Hepatotoxicity: Academic Case.

Mon, 10 Jun 2024 00:00:00 +0000

Isoniazid is used to treat or prophylaxis tuberculosis; However, its use may be associated with adverse liver reactions. Clinically overt hepatitis occurs in 0.5%-1% of patients receiving isoniazid as monotherapy. This clinical case reported allows the academy to always verify and monitor liver function in those who have medications that cause damage to liver cells.

Diagnosis of Empyema as a Complication of Liver Abscess in Peripheral Area

Stevia Ariella Pasande, Yoki Citra Perwira, Resyana Santoso — Wed, 12 Jun 2024 00:00:00 +0000

Right pleural empyema is one of the rare complications in liver abscess. This condition is life-threatening as it causes breathing difficulties and requires immediate life-saving. This case report aims to diagnose and manage empyema in a male patient with a liver abscess in a limited diagnostic setting. Methods: According to medical records, a 44-year-old man came to the emergency room (ER) of Umbu Rara Meha General Hospital with complaints of shortness of breath that had been getting worse for two months, accompanied by a cough with phlegm for one week, fever, and weight loss. The patient also complained of pain in the right upper abdomen for the last four months. History of pulmonary tuberculosis, diabetes mellitus, or hypertension was denied. The patient is not a smoker. On physical examination, there was an increase in the frequency of breathing and a decrease in the vesicular sounds on the right side. Right thorax X-ray examination revealed massive right pleural effusion without pulmonary infiltrates. Abdominal ultrasound showed a liver abscess. Emergency pleural puncture was performed in the ER, and 1600 cc of purulent pleural fluid was removed, followed by Water Sealed Draignase (WSD) installation. The patient was given intravenous broad-spectrum antibiotics and treated for 12 days.

Conclusion: Empyema can be a rare but life-threatening complication of liver abscess. Medical action must be taken immediately in the ER to save the patient. Delaying pus drainage can increase morbidity and mortality rates.

Comprehensive Review of Rothmund-Thomson Syndrome: Clinical Manifestations, Molecular Pathogenesis, and Therapeutic Approaches

Wed, 12 Jun 2024 00:00:00 +0000

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis characterized by a spectrum of clinical manifestations, including poikiloderma, sparse hair, short stature, skeletal abnormalities, and an increased predisposition to malignancies, particularly osteosarcoma. This syndrome is primarily associated with mutations in the RECQL4 gene, a critical player in DNA repair and genomic stability. This review provides an in-depth analysis of the clinical presentation, underlying molecular mechanisms, and current therapeutic strategies for RTS. We aim to elucidate the genetic and cellular pathways implicated in RTS, highlight the challenges in clinical management, and explore potential future directions in research and therapy.

Effectiveness of Proprioceptive Neuromuscular Facilitation and Strengthening Exercise towards Increasing Strength Stroke Patient's Hand Muscles at Tani Dan Nelayan Regional General Hospital

Karsum Y. Nauko, Sunarto Kadir, Muhammad Isman Jusuf — Wed, 12 Jun 2024 00:00:00 +0000

Stroke is a functional brain disorder that occurs suddenly with focal or global clinical signs that last more than 24 hours without signs of non-vascular causes, including signs of subarachnoid hemorrhage, intracerebral hemorrhage, ischemia, or cerebral infarction. The aim of this research is to analyze the effectiveness of proprioceptive Neuromuscular Facilitation (PNF) and Strengthening Exercises to Increase Hand Muscle Strength in Stroke Patients at the Farmers and Fishermen's Hospital, Boalemo Regency. Quaisy experimental research designed two groups pre-test and post-test design. The sample was 30 people, sampling used the purposive sampling technique. Analysis was carried out using the paired t-test and independent t-test. The results of the research were that there was a difference in Hand Muscle Strength values between those given Proprietary Neuromuscular Facilitation (PNF) with Strengthening Exercise with (p-value 0.039). The conclusion of this research is the provision of Proprioceptive Neuromuscular Facilitation (PNF). better in increasing hand muscle strength values compared to the Strengthening Exercise. It is recommended that the Farmers and Fishermen's Hospital of Boalemo Regency, in providing healing to stroke patients, apply Proprioceptive Neuromuscular Facilitation and Strengthening Exercise therapy as a complementary therapy for healing stroke patients.

Cardioprotective Effects of SGLT2 Inhibitors in Diabetic Patients with Cardiovascular Disease

Wed, 12 Jun 2024 00:00:00 +0000

Type 2 diabetes is a chronic and multifactorial disease associated with a twofold increase in the incidence of numerous cardiovascular and renal diseases, which are a significant health limitation for patients with diabetes. Throughout the years, cardiovascular diseases have marked a significant health burden in these patients. Many studies have shown that Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular mortality in patients with diabetes mellitus, by inhibiting cardiomyocyte apoptosis. Patients with diabetes are at a higher mortality risk after their first event of myocardial infarction than those without diabetes. The keystone in the therapy of diabetic patients is significantly linked to the prevention of cardiovascular events.

The high prevalence of cardiovascular and renal disease in patients with diabetes, as well as suboptimal glycemic controls and the significance of cardiovascular and renal risk reduction in type 2 diabetes, suggest that SGLT2 inhibitors have a significant clinical advantage, enhancing not just a better glycemic control, but improving cardiovascular and renal outcomes.

Cutaneous lupus subtypes

Thu, 13 Jun 2024 00:00:00 +0000

A broad spectrum of dermatologic manifestations, known as cutaneous lupus erythematosus (CLE), may or may not be linked to the development of systemic disease. There are numerous subtypes of cutaneous lupus, such as acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and chronic cutaneous lupus (CCLE). CCLE encompasses lupus tumidus, chilblain cutaneous lupus, LE profundus (LEP), and discoid lupus erythematosus (DLE). In order to diagnose these diseases, it is necessary to accurately classify the subtype. This is achieved through a combination of physical examination, laboratory studies, histology, antibody serology, and occasionally direct immunofluorescence, while also excluding systemic disease. The treatment of cutaneous lupus involves the provision of appropriate topical and systemic agents, as well as patient education regarding solar protection. In cases where the disease is pervasive, scarring, or treatment-refractory, systemic agents are recommended. In this chapter, we address the classification and diagnosis of the diverse subtypes of CLE and offer a comprehensive update on therapeutic management.

Percutaneous Repair of Calcified Valve Rings: Innovations and Clinical Outcomes in Interventional Cardiology

Thu, 13 Jun 2024 00:00:00 +0000

The advent of percutaneous repair techniques for calcified valve rings represents a significant advancement in interventional cardiology, addressing the complexities associated with valvular calcification. This article provides a comprehensive review of the current methodologies employed in the percutaneous repair of calcified valve rings, emphasizing the technological innovations, procedural strategies, and clinical outcomes. The discussion encompasses the pathophysiology of valvular calcification, patient selection criteria, and the evolution of device technology. Furthermore, it critically examines the efficacy and safety profiles of various interventional approaches, with a focus on post-procedural hemodynamic performance, long-term durability, and patient quality of life. By analyzing recent clinical trials and real-world data, this review aims to delineate best practices and future directions in the management of calcified valvular disease.

Comprehensive Neurological Examination in Intubated Patients: A Focused Neurology Perspective

Thu, 13 Jun 2024 00:00:00 +0000

The neurological examination of intubated patients presents unique challenges due to the lack of verbal communication and the need for sedation management. This article delves into the methods and best practices for conducting a thorough neurological evaluation in intubated patients, emphasizing the importance of adapting standard neurological assessment techniques to this special population. We explore the use of alternative communication methods, such as eye movements and motor responses, and the interpretation of these findings in the context of critical illness. The article also discusses the implications of sedation and neuromuscular blockade on neurological assessment and provides guidelines for optimizing the accuracy of the examination. By integrating a focused neurology perspective, this review aims to enhance the clinician’s ability to diagnose and monitor neurological status in intubated patients, ultimately improving patient outcomes in the intensive care setting.

Correlations between Body Mass Index (BMI) and Occurance of Metabolic Syndrome on Patients in Hospital Internal Medicine Clinic

Ryka M. Walanda, Dhea A. Rahmah — Thu, 13 Jun 2024 00:00:00 +0000

Body Mass Index (BMI) is the index used to classify and score overweight and obesity. An imbalance between energy intake and expenditure may cause the accumulation of fat in the body, which affects the BMI value. BMI is used to detect metabolic syndrome, which is a collection of symptoms that can increase the risk of non-communicable diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular disease. This study aims to determine the correlations between BMI and the incidence of metabolic syndrome at the internal medicine clinic Anutapura Hospital, Palu. This research was an analytic observational study with a cross-sectional approach. The samples were 96 patients and ATP III criteria was used in the assessment of metabolic syndrome. Individuals were declared metabolic syndrome if they met 3 out of 5 criteria, namely increased waist circumference, blood pressure, fasting plasma glucose (FPG), triglyceride levels, and decreased HDL levels. Data analysis used a chi-square test. It obtained a p-value = 0.001 with the results that showed a correlation between BMI and the incidence of metabolic syndrome at the internal medicine clinic, Anutapura General Hospital, Palu. There were correlations between BMI and waist circumference (p = 0.000), blood pressure (p = 0.003), triglycerides (p = 0.000), and HDL (p = 0.000). There were no correlations between BMI and FPG levels (p = 0.531). There is a correlation between BMI and the incidence of metabolic syndrome in the internal medicine clinic Anutapura Hospital, Palu.

The Importance of Early Diagnosis in Pediatric Oncology

Fri, 14 Jun 2024 00:00:00 +0000

Childhood cancer has its own very different characteristics from adult cancer. The cells that suffer a mutation in the genetic material are unable to mature as they should and remain with similar characteristics to the embryonic cell, multiplying rapidly and in a disorderly manner.The main objective of this article is to describe some of the generalities of childhood tumors and to describe the warning signs that should prompt pediatricians to refer their patients to a specialist. This article is a systematic review, based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, which seeks to identify the types of childhood cancer and treatment regimens established by the current literature on the subject. Cancer treatment begins with a correct diagnosis, which requires the participation of a reliable laboratory and imaging studies. Due to its complexity, treatment must be carried out in a specialized center and comprises three main modalities (chemotherapy, surgery and radiotherapy, when necessary), being applied rationally and individually for each specific tumour and according to the extent of the disease. The work coordinated by a multi-professional team is also a determining factor in the success of the treatment. Most of the symptoms of Childhood Cancer are much more likely to be caused by other reasons, such as an injury or infection. Even so, if your child has any of the symptoms mentioned in this article, consult a doctor so that the cause can be diagnosed and, if necessary, treatment started.

Resuscitation Guided by Cardiac Output using Transesophageal Echocardiography in Kidney Transplantation: Case Report.

Fri, 14 Jun 2024 00:00:00 +0000

Introduction: During kidney transplant, monitoring fluid administration is essential to ensure graft function. Transesophageal echocardiography measures the impact of fluids/medications on real time at myocardium.

Case Report: A 28-year-old female patient who underwent a kidney transplant with cardiac output resuscitation by transesophageal echocardiography: Initially, the patient presented a hypovolemic profile that responded to crystalloid infusion. By monitoring the cardiac output, fluid accumulation syndrome is avoided, leading to a distributive profile where the state of dynamic overload is physiologically de-escalated after reperfusion.

Discusion: Cardiac output-guided resuscitation using transesophageal echocardiography ensures tissue perfusion without fluid accumulation in kidney transplant surgery.

The Potential Therapeutic Role of Flavonoids and Mangiferin in Mango Peel for Burn Wound Healing: A Comprehensive Literature Review

Fri, 14 Jun 2024 00:00:00 +0000

Background: Approximately 11 million burn injuries occur worldwide each year, causing significant morbidity and emotional distress. Burn wounds heal slowly, impacting quality of life. Mango peel contains flavonoids and mangiferin, which may aid burn wound healing.

Objectives: This literature review aims to explore flavonoids and mangiferin in mango peel for burn wound healing.

Methods: We searched PubMed, Google Scholar, Scopus, and Web of Science using keywords like burn wound, thermal injuries, flavonoid, mangiferin, and mango peel. We included accessible articles in Bahasa Indonesia or English, including research articles, systematic reviews, meta-analyses, and literature reviews.

Discussion: Flavonoids enhance collagen synthesis and increase fibroblast basic growth factor and vascular endothelial growth factor, promoting granulation tissue formation. Mangiferin has anti-inflammatory properties, suppressing COX-1, COX-2, and PGE-2 production, and deactivating the NLRP3 inflammasome. These actions suggest potential for improving burn wound healing.

Conclusion: Flavonoids and mangiferin in mango peel show promise for wound healing due to their anti-inflammatory, antibacterial properties, and ability to stimulate collagen and VEGF formation. Further research is needed for clinical application and better outcomes.

Trends in Cleft Lip and Palate Surgery: A Half-Century Bibliometric Analysis and Literature Review

Naufal A. Rahman, Santi Devina, Masyithoh W. Diani — Fri, 14 Jun 2024 00:00:00 +0000

Introduction: Cleft lip and palate (CLP) are significant congenital anomalies requiring comprehensive surgical and multidisciplinary care. This study conducts a bibliometric analysis CLP surgery research to identify key authors, topics, and journals, highlighting collaboration trends and providing insights into current research and future directions.

Methods: The data was acquired online from Scopus on May 22^nd, 2024 with a search spanning from 1974 to 2024, yielding 7,283 relevant documents. The publication output was then analyzed using VOSViewer to provide the visual representation.

Results and Discussion: The results indicate an increase in research studies over the years. Lo, L.J. emerged as the top researcher, with the United States leading in research output. Researchers primarily focused on three areas: surgical techniques, complications, and secondary procedures. Emerging areas such as patient quality of life, velopharyngeal insufficiency, and nonsyndromic clefting are gaining interest for future research.

Conclusion: Significant progress in CLP surgery has improved patient outcomes and quality of life over the past fifty years. Continued research and international collaboration are essential to address global disparities and ensure equitable access to advanced CLP care, further enhancing outcomes and quality of life for all patients.

Epidemiological Analysis of the Sequelae of Orbital Trauma in the Mexican Population of a National Concentration Hospital; Traumatology Hospital "Dr. Victorio De La Fuente Narváez" IMSS

Fri, 14 Jun 2024 00:00:00 +0000

Objective: To determine the epidemiological profile of the sequelae of orbital trauma in the Mexican population of a hospital of national concentration; in the period between January 1, 2013 and March 31, 2017.

Design: Observational, retrospective and transversal.

Methodology: Collection of data from clinical files of patients seen in Ophthalmology with diagnosis of orbital trauma (1002 patients); subsequently, they were recorded in a database and the information was emptied in SPSS for statistical analysis.

Results: The presence of sequelae was related to the type of trauma, the method of reconstruction and the approach employed. 60.38% of the cases presented sequelae. When evaluating the orbital sequelae associated with orbital fractures, it was observed that the most frequent sequels were Mechanical Strabismus, Diplopia, Anisocoria and Enophthalmos. In none of these associations was a significant p value obtained in the Chi-square test, however none exceeded the unit.

Conclusions: Patients with orbital trauma are increasing. It was observed that the most frequent fracture is the floor fracture and therefore in which more sequels are observed so we must be careful to prevent or minimize them intentionally. The most prevalent postoperative sequelae were diplopia and mechanical strabismus. In this study, important epidemiological data were obtained that can help to broaden knowledge and guide the personnel who treat orbital trauma to prevent and / or minimize sequelae, providing a better functional and aesthetic prognosis.

Disseminated Superficial Actinic Porokeratosis: Case report

Tue, 18 Jun 2024 00:00:00 +0000

Background: Disseminated superficial actinic porokeratosis is a rare disorder that presents abnormal clonal keratinization of unknown etiology. Frequently associated with UV radiation, genetic factors, and immunosuppression. It manifests clinically as solitary or multiple annular plaques surrounded by a hyperkeratotic border. Various clinical forms have been described, including disseminated superficial actinic porokeratosis, the most common subtype and represented in the following clinical case.

Clinical case: A case of a 62-year-old male is presented who presents with dermatosis characterized by annular erythematosquamous plaques spread to the hands, chest and upper and lower extremities and chest with collarette scales of chronic evolution. A clinical diagnosis is made, confirmed by classic histopathology and dermoscopic findings.

Conclusions. Disseminated superficial actinic porokeratosis is rare, difficult to diagnose and similar to multiple pathologies; This is why it is important to recognize them clinically and achieve timely treatment of potential malignancy that they present.

Upper Eyelid Blepharoplasty: An Aesthetic and Functional Repair

Tue, 18 Jun 2024 00:00:00 +0000

Upper blepharoplasty is a popular cosmetic surgery technique, with a yearly demand growth of 6%. It is primarily performed on women, aged between 50 and 70, to rejuvenate the look, enhance the supratarsal crease, and rectify contour abnormalities. The procedure also has functional advantages, such as enhancing the upper field of vision and reducing ptosis. In a clinical scenario, patients with eyelid scars experienced eyelid retraction, lagophthalmos, and ulcerative keratitis. Initially, supportive care was performed, followed by surgical treatment, including scar band release, full-thickness skin graft, eyelid closure, and tarsorrhaphy. Positive results included an expanded visual field, improved quality of life, reduced headaches, and enhanced eyesight. However, further investigation is needed due to contradictory findings and lack of scientific data. We present an interesting case of a patient in whom reconstruction was performed for aesthetic-functional purposes.

Spontaneous Coronary Artery Dissection and Tear Repair: A Comprehensive Review of Pathophysiology, Diagnosis, and Therapeutic Interventions

Wed, 19 Jun 2024 00:00:00 +0000

Spontaneous Coronary Artery Dissection (SCAD) represents a rare but significant cause of acute coronary syndrome, predominantly affecting young to middle-aged women without traditional cardiovascular risk factors. The pathophysiology of SCAD involves the spontaneous development of an intimal tear or the formation of an intramural hematoma, leading to coronary artery obstruction and myocardial ischemia. Diagnosing SCAD is challenging due to its varied presentation and the need for high-resolution imaging techniques. Management strategies for SCAD are diverse, ranging from conservative medical therapy to percutaneous coronary intervention (PCI) and, in severe cases, surgical repair. This review aims to provide a detailed analysis of the pathophysiological mechanisms, diagnostic criteria, and therapeutic approaches for the repair of SCAD, highlighting recent advancements in interventional cardiology and surgical techniques.

The Effectiveness of the Α-Amylase Enzyme Inhibition by Several Traditional Medicinal Ingredients Black Turmeric, Aromatic Ginger, Black Cumin, Forest Bee Honey and Sweet Leaves in Ready to Drink Formulation

Prayoga Eko Nuryadi, Siti Juariah, Serli Alnamira Lorenza, Susi Endrini — Wed, 19 Jun 2024 00:00:00 +0000

The inhibition of α-amylase enzymes can delay the remaining carbohydrates in the small intestine and reduce the travel of postprandial blood glucose, therefore the content of compounds in the form of tannins, flavonoids, saponins and terpen is believed to be able inhibit the α-amylase enzymes. Knowing the effectiveness of α-amylase enzyme inhibition by some traditional medicine ingredients (Curcuma caesia, Kaempferia galanga, Nigella sativa, Apis dorsata, and Stevia rebaudiana) and organoleptic properties of the ready to drink formulation. This study is an experimental study using the design "Pretest-Posttest with control Groug" on the sample in the form of liquid extracts. Plant liquid extract is tested for its inhibition of α-amylase and used as a formulation of herbal drink ready to drink. The result IC₅₀ values of black turmeric extract (6.46 mg/ml), aromatic ginger (6.10 mg/ml), black cumin (7.36 mg/ml), forest bee honey (2.59 mg//ml) and sweet leaves (4,85 mg/ml). The results of IC50 formulations 1 (8.03 mg/ml) and 2 (14.18 mg/ml) and glibenclamide values are (2.53 mg/ml). Conclusion the effectiveness of α-amylase inhibition of sweet leaf extract is better than other extracts and formulation 1 is better than formulation 2.

Functional and Aesthetic Outcomes in Facial Reconstructions with Multiple Composite Axial Flaps – Case Report

Eugen Gabriel Turcu, Dan Alexandru Oltean, Matei Gheorghiu Branaru — Wed, 19 Jun 2024 00:00:00 +0000

The article presents a case of facial reconstruction with several facial axial flaps for a posttraumatic defect of the left upper lip, medial cheek region and left nasal wing.

The case refers to a 58-year-old patient who is hospitalized for a facial trauma which involves only the soft tissues, resulting from a car accident.The immediate reconstruction of all the affected aesthetic units using multiple reconstructive techniques allowed the favorable resolution of the case in the shortest possible time. We used advancement and rotation orbicularis oris innervated musculocutaneous flaps for reconstruction of the left upper lip, cervicofacial cutaneous flap for the medial cheek defect and composite forehead flap for the reconstruction of the left nasal wing. The simultaneous use of different types of flaps made possible the total healing after 4 weeks after the accident and the social and professional integration of the patient.Complex facial trauma often involves both skeletal and soft tissue damage, presenting significant challenges in both initial management and long-term reconstruction. These injuries can result from various etiologies including motor vehicle accidents, assaults, sports injuries, and falls. Effective treatment requires a multidisciplinary approach to address the intricate anatomy and functional importance of facial structures.

The Effect of Dental Health Education through Leaflet Media on Student's Knowledge

Restika Anindya Pinasti, Ghita Hadi Hollanda, Bambang Sucahyo — Wed, 19 Jun 2024 00:00:00 +0000

Introduction: The children aged 6-14 years are an age group that is critical for the occurrence of dental caries and has special characteristics, namely the period of replacement of deciduous teeth with permanent teeth. This group has a fairly high prevalence rate of dental caries, reaching 60-80%. In general development, dental caries looks very active at ages 4-8 years and ages 11-19 years. Based on the initial inspection at Hang Tuah 6 Elementary School Surabaya, there were 43 students with DMF-T index amount 4.5 in the high category. And the remaining data was obtained from 37 students, only 2 students were caries free. And it can be seen that the DMF-T index of 8.1 is a problem in this research, namely the high percentage of dental caries in students in 5th and 6th grade at Hang Tuah 6 Elementary School Surabaya in 2023. Purpose: This study purposes to analyze the relationship between knowledge on dental health education using leaflet media.

Materials and Methods: The sampling technique used in this research is purposive sampling. The criteria for this research sample were students in 5th and 6th grade at Hang Tuah 6 Elementary School Surabaya. Data analysis using a simple linear regression statistical test with the aim of comparing the average results of the pre-test with the post-test in the intervention group, the decision to test the research hypothesis is based on the significant level < 0,05.

Results: The characteristic of the respondents who were research subjects included age, gender, and number of students in each class. there is a variable influence of providing education through leaflet media on student's knowledge of dental and oral health Hang Tuah 6 Elementary School Surabaya. The table also explains the magnitude of the correlation/relationship value (R), which is 0.208. From this output, a coefficient of determination (R square) of 0.043 is obtained, which means that the independent variable to the dependent variable is 4,3%.

Conclusions: The effect of dental health education using leaflet media on dental and oral health knowledge among students at Hang Tuah 6 Elementary School, Surabaya in 2023, this is based on a ρ value of 0.000<0.05, where H0 rejected and Ha accepted.

Dermal Autografts in Plastic Surgery: Advances, Techniques, and Clinical Outcomes

Fri, 21 Jun 2024 00:00:00 +0000

The utilization of dermal autografts in plastic surgery has evolved significantly over the past few decades, offering a versatile and reliable method for the reconstruction of various tissue defects. This article reviews the current advancements in dermal autografting, with a focus on the latest surgical techniques, integration with regenerative medicine, and the clinical outcomes observed in diverse patient populations. We discuss the biological basis of autograft survival and integration, highlight innovative approaches to enhance graft viability, and analyze complications associated with these procedures. The article also explores the role of autologous dermal grafts in aesthetic and reconstructive surgery, providing insights into future directions for research and clinical practice.

Relationship Between Some Cardiovascular Risk Factors (Hypertension and Diabetes) and Hearing Loss: A Review and Critical Appraisal

Fri, 21 Jun 2024 00:00:00 +0000

Cardiovascular disease and its risk factors are no longer only problems in developed countries, they are equally prevalent in developing countries. Cardiovascular risk factors have been hypothesized to play a role in the pathogenesis of hearing loss. Specifically, hypertension and diabetes mellitus can affect the cochlear microvasculature, leading to cochlear atherosclerosis. These atherosclerotic changes may result in impairment of local micro-cochlear circulation, causing ischemia and necrosis of the stria vascularis, hair cells, and the entire organ of Corti, and this may lead to hearing loss. The effect of cardiovascular risk factors on hearing is still under investigation. The aim of this study is to review the relationship between cardiovascular risk factors (hypertension and diabetes) and hearing loss.

Does The Scientific Evidence Support the Idea of Promoting Sucralfate as The First Aid Topical Management for Burn Wound? A Literature Review

Angela Maria Linata, Ahmad Fawzy — Fri, 21 Jun 2024 00:00:00 +0000

Burn injuries, caused by heat, chemicals, radiation, or electricity, significantly impact morbidity and mortality. Sucralfate, a mucoprotective agent composed of sucrose sulfate and aluminum hydroxide, forms a protective barrier on wounds, reduces pain, stimulates healing, and has anti-inflammatory effects. By stimulating prostaglandin secretion and binding to proteins in the ulcer bed, sucralfate enhances gastrointestinal mucosa defenses and acts locally in injured tissues, minimizing systemic effects. Clinical studies demonstrate its effectiveness in improving wound healing, reducing pain, and promoting tissue regeneration, angiogenesis, and granulation tissue development in burn patients. For optimal burn wound therapy, proper patient selection, formulation techniques, and integration with standard protocols are crucial. Further large-scale randomized controlled trials are necessary to establish guidelines and expand sucralfate's clinical applications.

Correlation of the Score Obtained Through The “Functional Movement Screen” (FMS) Test with The Incidence of Musculoskeletal Injuries in Players of The Mexican Professional Basketball League (LNBP) During The 2023 Season

Mon, 24 Jun 2024 00:00:00 +0000

Background. The assessment of mobility is important to determine the degree of functionality inherent in the ability to move and, therefore, sports performance. Likewise, mobility is related to the development of musculoskeletal injuries, but this is little known in professional basketball players.

Objective. Correlation of the FMS score with the incidence of musculoskeletal injuries in LNBP players during the 2023 season.

Methodology. An observational, cross-sectional, analytical, prospective study was conducted on professional basketball players from the Mexican League who played during the 2023 season. Before the start of the 2023 season, the FMS test was performed on the players. Other useful information for the study was recorded: history of musculoskeletal injuries, presence of pain, or limitation to movement at the time of the test. After that, a follow-up was carried out throughout the 2023 season to identify if the players had any musculoskeletal injury, including fracture, muscle injury, connective tissue injury (meniscal, capsular, fascial, etc.), ligamentous injury, tendinopathy, and low back pain. A musculoskeletal injury was defined as physical damage to the body secondary to athletic activity or an event for which the athlete sought medical attention and resulted in modified training or required splitting or protective taping. The affected joint or body site (knee, ankle, elbows, shoulders, wrist, other) and the number of injuries during the season were also recorded. Finally, the information was captured in the SPSS v.26 statistical program to determine if there were significant correlations between the scores obtained from the FMS test and the incidence of musculoskeletal injuries.

Results. Among the 27 players, the average age was 29.4±3.7 years (range 21-39 years). The overall incidence of musculoskeletal injuries throughout the season was 88.9%, only 3 players did not present musculoskeletal injuries (11.1%). The average was 2.7±1.4 injuries per player throughout the season. First-time injuries represented 69.2% of the cases and recurrent injuries represented 30.8%. 41.5% of the players had a minor injury, 36.9% mild, 10.8% moderate, and 10.8% severe. The mean FMS score was 14.5±1.8. The Pearson correlation between the FMS score and the number of lesions was r=0.084 (p=0.900). There were no significant differences in games lost, days out, and number of injuries, but there was a trend toward fewer games lost and days out in players with more than 14 points on the FMS scale. No significant differences were found in the FMS score by injury severity (p=0.472). The area under the curve for predicting moderate-severe musculoskeletal injuries based on the FMS score was 0.581 (0.419-0.742, p=0.359). In those over 30 years of age, a significant correlation of the FMS score with age was found (r=-0.406), but not in those under 30 years.

Conclusion. The incidence of musculoskeletal injuries was high. Although the FMS score was not a determining predictor for its development, our study suggests its potential usefulness in identifying players with a higher risk of severe injuries, especially individuals over 30 years.

Advancements in Gene Therapy and Stem Cell Applications in Interventional Cardiology: A Comprehensive Review

Tue, 25 Jun 2024 00:00:00 +0000

Gene therapy and stem cell applications represent the forefront of innovative treatments in interventional cardiology, offering potential solutions for previously intractable cardiovascular conditions. This review explores the current advancements, mechanisms, and clinical implications of gene therapy and stem cell technologies in the treatment of ischemic heart disease, heart failure, and myocardial infarction. The integration of these modalities into interventional procedures has the potential to revolutionize patient outcomes by promoting myocardial repair, enhancing angiogenesis, and improving cardiac function. Despite promising preclinical and early clinical results, challenges such as delivery methods, immunogenicity, and long-term efficacy remain. This article provides a detailed analysis of the latest research, clinical trials, and future directions in the field, highlighting the transformative potential and obstacles that need to be addressed for widespread clinical adoption.

A-38-Years-Old Woman a Case of SLE Having Four Successful Replacement Therapy: Bilateral Hip Replacement for Bilateral Avascular Necrosis of Femoral Head, Maintenance Hemodialysis Followed by Living Donor Kidney Transplant for End Stage Renal Disease

Wed, 26 Jun 2024 00:00:00 +0000

CASE SUMMARY

A-38-years-old woman, a case of SLE, had avascular necrosis of both femoral heads and end stage renal disease 5 years and 8 years after diagnosis. Therefore, maintenance hemodialysis was initiated. Total hip replacement was done one after another successfully. Three months after replacement of hip, living donor kidney transplant was done with success. We reviewed the current literature.

Association between ST-Segment Resolution Following Thrombolysis and Reperfusion of Infarct Related Artery in Coronary Angiogram in Patients with ST-Segment Elevation Myocardial Infarction

Wed, 26 Jun 2024 00:00:00 +0000

Background: ST-segment elevation myocardial infarction (STEMI) is the most critical form of acute coronary syndrome as having the worst overall prognosis. Following thrombolysis, if it is possible to reliably predict about the reperfusion status by means of a non-invasive, readily available tool like ECG, it will help the clinicians to determine the quality of reperfusion and select the next strategy of management. The aim of the study was to assess angiographic findings of TIMI flow in infarct related artery (IRA), compared to the ranges of ST-segment resolution, and determine their association to predict reperfusion in IRA.

Methods: Thiscross-sectional observational study was conducted in the department of Cardiology at National Institute of Cardiovascular Diseases (NICVD), Dhaka, for 12-months following ethical approval. A total of 116 adult patients with acute STEMI who underwent thrombolysis with streptokinase were enrolled by convenient sampling method after taking written informed consent. The percent resolution of ST-segment deviation from baseline to 60 minutes following thrombolysis was compared with angiographic IRA TIMI flow grade in index hospitalization. Detailed history, thorough clinical examination and necessary investigations were carried out in each patient and recorded in predesigned structured questionnaire. Data were analyzed by SPSS 26.0.

Results: The mean age of the patients was 50.8 ± 8.8 years with male predominance (77.6%). Among all, 45.7% had >70% ST resolution followed by 29.3% had 30-70% and 25% had <30% ST resolution. Regarding TIMI grade flow, 59.1% had grade-3, 22.7% had grade-2 and 18.2% had grade 0 or 1. TIMI grade flow significantly increased with the increased ST-segment resolution. A cut off value of ST-segment resolution ≥57.5% (AUC=0.771, 95% CI=0.684-0.858, p<0.001) in the prediction of TIMI grade flow 3 showed 67.69% sensitivity, 66.67% specificity, 74.58% PPV, 58.82% NPV and 67.27% accuracy. Multivariate logistic regression shows that timing of thrombolysis, >70% ST resolution showed higher odds ratio and >70% ST resolution showed statistically significant p-value for predicting TIMI grade flow 2 or 3.

Conclusion: ST-segment resolution in electrocardiogram following thrombolysis has significant positive association with TIMI flow of infarct related artery in coronary angiogram. However, further larger study is recommended.

Bowel Obstruction Secondary to Gallstone Ileus: A Diagnostic Challenge - Case Report

Thu, 27 Jun 2024 00:00:00 +0000

Biliary ileus is an unusual cause of intestinal occlusion in the general population (<5%), secondary to the impaction of a biliary stone in the digestive tract due to the presence of a bilioenteric fistula, a rare complication of cholelithiasis. A 65-year-old woman with intestinal occlusion secondary to biliary ileus, diagnosed by abdominal computed tomography, underwent open enterolithotomy. Post-surgery, the patient's symptoms resolved without complications. The treatment objective for biliary ileus is to relieve the obstruction, typically through enterolithotomy, although there is no definitive standardized surgical technique. This case report includes a brief literature review.

Insights into Laron Syndrome: Unraveling the Molecular Basis, Clinical Manifestations, and Therapeutic Prospects

Fri, 28 Jun 2024 00:00:00 +0000

Laron Syndrome, a rare and intriguing genetic disorder, stands as a testament to the intricate interplay between genetics and endocrinology. This article delves into the comprehensive exploration of Laron Syndrome, elucidating its molecular underpinnings, intricate clinical presentations, and the evolving landscape of therapeutic interventions. By synthesizing current research and clinical observations, we aim to enhance the understanding of this syndrome, shedding light on the challenges posed by its unique pathophysiology. The exploration of growth hormone receptor insensitivity, molecular signaling cascades, and associated comorbidities will be discussed in detail, providing a foundation for future advancements in both diagnostic approaches and therapeutic strategies.

The Advanced Management of a Burn Patient

Sat, 29 Jun 2024 00:00:00 +0000

Burn injuries pose a serious public health issue, contributing to a considerable worldwide impact. These injuries can lead to intricate and perhaps fatal scenarios that necessitate sophisticated care procedures. This review examines the study of the occurrence, importance, and advanced treatment of individuals with burn injuries. We explore the theoretical framework, encompassing definitions, risk factors, complications, and diverse management strategies. The conversation focuses on the most recent developments in burn treatment, such as prompt removal of burn wounds, replenishing fluids, managing infections, and facilitating rehabilitation. The focus is placed on the changing field of burn care research and how it might lead to better results for patients. To summarize, this article emphasizes the significance of utilizing a variety of disciplines in the treatment of burn patients and the necessity for ongoing study to improve the well-being of those who have survived.

An Analysis of Flaps in Reconstructive Surgery

Sat, 29 Jun 2024 00:00:00 +0000

This literature review article will provide a comprehensive analysis of flaps in reconstructive surgery, specifically discussing their description, indications, problems, and treatment. This study will investigate the epidemiology of flaps and their clinical importance. This text will address the procedures employed in the application of flaps, emphasizing the significance of preoperative planning and surgical approaches. Furthermore, this text will delve into the intricacies linked to flaps and provide a thorough analysis of the benefits and difficulties involved with their utilization in reconstructive surgery. A summary highlighting the essential elements of this evaluation will be presented.