Exploring the Role of Micrornas in Wound Healing
Main Article Content
Abstract
Wound healing is a complex process involving inflammation, cellular proliferation, and matrix remodeling. However, skin's regenerative capacity varies across species, and adult mammals, including humans, have limited ability to fully regenerate tissue. Scar formation is a common outcome of wound healing, impacting quality of life. MicroRNAs (miRNAs) are key regulators in wound healing, influencing inflammation, cell proliferation, angiogenesis, and matrix remodeling. Dysregulated miRNAs can impair wound healing. Additionally, miRNAs play roles in wound healing, autoimmune diseases, and allergies. Understanding miRNA involvement offers insights into mechanisms and potential therapies for managing these conditions.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
I. Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ. Wound healing. J Chin Med Assoc. 2018;81(2):94-101.
II. Takeo M, Lee W, Ito M. Wound healing and skin regeneration. Cold Spring Harbor perspectives in medicine. 2015;5(1):a023267.
III. Gantwerker EA, Hom DB. Skin: histology and physiology of wound healing. Facial plastic surgery clinics of North America. 2011;19(3):441-53.
IV. Banerjee J, Sen CK. microRNA and Wound Healing. Advances in experimental medicine and biology. 2015;888:291-305.
V. Jiang Y, Xu X, Xiao L, Wang L, Qiang S. The Role of microRNA in the Inflammatory Response of Wound Healing. Frontiers in immunology. 2022;13:852419.
VI. Tahamtan A, Teymoori-Rad M, Nakstad B, Salimi V. Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment. Frontiers in immunology. 2018;9:1377.