Waldenstrom Macroglobulinemia, a Rare Hematological Malignancy:

Main Article Content

Dr. Ancy Mathew
Dr. Priya V.S.

Abstract

Waldenstrom macroglobulinemia is a rare hematological malignancy which accounts for
only about 1% of the diagnosis. It is unique among B cell malignancies that usually produce a large amount of immunoglobulin M(IgM). Some patients may be symptomatic commonly fatigued due to anemia, bleeding or neurologic complaints, while others may be asymptomatic. There is a greater proportion of men and are diagnosed in their mid-60s. Here we report a case of a 58-yearold male who presented with increased fatigability. Routine blood investigation showed anemia with raised ESR and reversal of albumin globulin ratio.Bone marrow study was done to rule out multiple myeloma,which showed hypercellular marrow predominantly composed of atypical mononuclear cells with variable morphology from lymphocytes to plasma cells.Serum electrophoresis was adviced which revealed elevated serum

Article Details

How to Cite
Mathew, D. A., & Dr. Priya V.S. (2023). Waldenstrom Macroglobulinemia, a Rare Hematological Malignancy: . International Journal of Medical Science and Clinical Research Studies, 3(06), 1114–1118. https://doi.org/10.47191/ijmscrs/v3-i6-15
Section
Articles

References

I. WHO hematolymphoid neoplasm, 4th edition

II. Wintrobes clinical hematology, 14th edition

III. Hatem Kaseb;Luis F. Gonzalez Mosquera; Meghana Parsi, Prerna Mewawalla Lymphoplasmacytic lymphoma.

IV. 4.Kudo N, Usui M, Nakabo Y, Yoshida KI, Miki K, Osafune T, Nishimura K, Imashuku S. Waldenstrom's Macroglobulinemia: A Report of Two Cases, One with Severe Retinopathy and One with Renal Failure. Case Rep Hematol. 2017; 2017:3732902. doi: 10.1155/2017/3732902. Epub 2017 Oct 31. PMID: 29225979; PMCID: PMC5684595.

V. Gertz MA. Waldenström macroglobulinemia: 2017 update on diagnosis, risk stratification, and management. Am J Hematol. 2017 Feb;92(2):209-217. doi: 10.1002/ajh.24557. PMID: 28094456.

VI. 6.Merlini G, Baldini L, Broglia C, Comelli M, Goldaniga M, Palladini G, Deliliers GL, Gobbi PG, Prognostic factors in symptomatic Waldenstrom’s macroglobulinemia. Semin Oncol. 2003 Apr,30(2):211-5. doi:10.1053/sonc2003.50064. PMID: 12720138.