Importance of Telomeres in Their Potential Scope for Determining Aging
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Abstract
Aging has had and will have a considerable relevance in the population for millions of years. Various ways have been explored to prevent or prolong it, since aging is often accompanied by chronic degenerative diseases. Although not much information has been discovered about this, the participation of telomeres in aging has been studied. Telomeres are the ends of DNA that protect and prevent its degradation, however, the relationship of the presence of long telomeres to a long life has been contemplated in conjunction with the reduction of chronic degenerative diseases, so that these individuals have a more desirable quality of life than individuals who have shortened telomeres
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References
I. Squassina, A., Pisanu, C., & Vanni, R. (2019). Mood Disorders, Accelerated Aging, and Inflammation: Is the Link Hidden in Telomeres?. Cells, 8(1), 52. https://doi.org/10.3390/cells8010052.
II. Song, S., & Johnson, F. B. (2018). Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres. Genes, 9(4), 201. https://doi.org/10.3390/genes9040201. https://doi.org/10.3390/genes9040201
III. Sellami, M., Bragazzi, N., Prince, M., Denham, J., & Elrayess, M. (2021, August 6). Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime. Frontiers in genetics. Retrieved from https://www.frontiersin.org/articles/10.3389/fgene.2021.652497/full
IV. Muñoz-Lorente, M.A., Cano-Martin, A.C. & Blasco, M.A. Mice with hyper-long telomeres show less metabolic aging and longer lifespans. Nat Commun 10, 4723 (2019).
https://doi.org/10.1038/s41467-019-12664-x
V. Boccardi, M., & Boccardi, V. (2019). Psychological Wellbeing and Healthy Aging: Focus on Telomeres. Geriatrics (Basel, Switzerland), 4(1), 25. https://doi.org/10.3390/geriatrics4010025
VI. Chilton, W., O'Brien, B., & Charchar, F. (2017). Telomeres, Aging and Exercise: Guilty by Association?. International journal of molecular sciences, 18(12), 2573.
https://doi.org/10.3390/ijms18122573
VII. Brane, A. C., & Tollefsbol, T. O. (2019). Targeting Telomeres and Telomerase: Studies in Aging and Disease Utilizing CRISPR/Cas9 Technology. Cells, 8(2), 186. https://doi.org/10.3390/cells8020186.
VIII. Whittemore, K., Vera, E., Martínez-Nevado, E., Sanpera, C., & Blasco, M. A. (2019). Telomere shortening rate predicts species life span. Proceedings of the National Academy of Sciences of the United States of America, 116(30), 15122-15127. https://doi.org/10.1073/pnas.1902452116
IX. Córdoba-Lanús, E., Cazorla-Rivero, S., Espinoza-Jiménez, A., de-Torres, J. P., Pajares, M. J., Aguirre-Jaime, A., Celli, B., & Casanova, C. (2017). Telomere shortening and accelerated aging in COPD: findings from the BODE cohort. Respiratory research, 18(1), 59. https://doi.org/10.1186/s12931-017-0547-4
X. Armanios M. (2013). Telomeres and age-related disease: how telomere biology informs clinical paradigms. The Journal of clinical investigation, 123(3), 996-1002. https://doi.org/10.1172/JCI66370
XI. Prasad, K., Wu, M., & Bondy, S. (2017). Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents. UC Irvine. http://dx.doi.org/10.1016/j.mad.2017.04.004 Retrieved from
https://escholarship.org/uc/item/55093212
XII. Chakravarti, D., LaBella, K., & DePinho, R. (2021, January 14). Telomeres: history, health, and hallmarks of aging. Cell. Retrieved October 23, 2021, from
https://www.cell.com/cell/fulltext/S0092-8674(20)31750-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420317505%3Fshow all%3Dtrue#relatedArticles.
XIII. Williams Shay, J. (2018, June). Telomeres and aging. ScienceDirec Elsevier. Retrieved,from https://www.sciencedirect.com/science/article/abs/pii/S0955067417300509?via%3Di hubBooks
XIV. Jameson J. L. J., S. Fauci A. , Dennis L. Kasper, L. Hauser S. , Dan L. Longo, Loscalzo J. , Harrison. Principles of Internal Medicine, 20e (2020) Chapter 463: Biology of Aging.
XV. L. Kane R., Ouslander J.G., Resnick B., L. Malone M., Principles of clinical geriatrics, 8e (2018), Chapter 1: Clinical implications of the aging process.
XVI. W. Rodwell V., A. Bender D., Botham M. K., J. Kennelly P., Weil A., Harper Biochemistry Illustrated, 31e, (2018), Chapter 57: The biochemistry of aging.