Reviewing a Scarless Wound Healing:From Embryology to Post-Wound Management
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Abstract
Introduction: Scarring happens after trauma, injury or surgery to any tissue or organ in the body. Disturbing perceptions like pain, itchiness or tenderness from one perspective, and functional limitations in the form of contractures on the other, are ramification of problematic scars. In addition, scar esthetics can also have a negative influence on psychosocial factors. Various treatment options described in the literature include chemical, physical, and surgical methods. The purpose of physical scar treatment is primarily focused on preventing inappropriate healing of the skin
Methods: This literature review was compiled using information from numerous web databases, including NCBI, Google Scholar, Science Direct, and Pubmed. Data were analyzed.
Results: Good wound management is to reduce the incidence of scar tissue in the wound. Embryonic scarless wound healing is a form of wound healing in the embryo and results in scarless wounds. Many in vivo studies have been carried out on several experimental animals, and the molecules that play a role are examined. Molecules that play a role in scarless and scarring wound healing are TGF-β 1, 2, and 3. TGF-β 1 and 2 play a role in the formation of scar tissue, while TGF-β3 plays a role in tissue regeneration. There is a hypothesis that TGF-β3 injected into the tissue will help wound healing and increase tissue regeneration so that scarless wound healing occurs.
Conclusion:. Molecules that play a role in scarless and scarring wound healing are TGF-β 1, 2, and 3. TGF-β 1 and 2 play a role in the formation of scar tissue, while TGF-β3 plays a role in tissue regeneration. Scarless and scarring wound healing is not only based on the molecules that play a role but healing time and injured tissue also have an effect on wound formation. scarring and scarless wound healing can also occur in the same individual and the same individual tissue
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