Correlation between Histopathologic Features and β-HCG Levels in the Event of Hydatidiform Mole
Main Article Content
Abstract
Background: Hydatidiform mole is a gestational trophoblastic disease with the highest incidence in Indonesia where the incidence is 1 in 40 pregnancies. The cause of the high incidence of Hydatidiform mole is influenced by the reproductive performance of patients such as disorders of the hypothalamic-pituitary-ovarian system which causes hyperproliferation of trophoblastic cells, hydrophic degeneration of chorionic villi, and increased levels of β-hCG.
Methods: This research was involving human subjects so that was related to the issues of ethical consideration. It was done at the Anatomical Pathology Laboratory and the medical record division of the Hasanuddin University Hospital and Dr Wahidin Sudirohusodo Hospital Makassar from September - November 2019. The number of samples was 28 which used the total sampling method that fulfill the inclusion and exclusion criteria. Data analysis used chi-square.
Results: There are correlation between the histopathologic features with β-hCG levels, they are hydrophic degeneration of chorionic villi with β-hCG levels (p= 0.008) and proliferation of trophoblast cell with β-hCG (p= 0.001).
Conclusions: There is a correlation between the histopathologic features and β-hCG levels in the event of hydatidiform mole at Hasanuddin University Hospital and Dr. Wahidin Sudirohusodo Hospital Makassar. The higher levels of β-hCG, the histopathologic features of hydropic degeneration villi will increase and trophoblastic cells will become hyperproliferation.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
I. Allison A.G., Lawrence H.L, Michelle D., Alexander M., Anthony R., Sue Y., Kevin E., et all. Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy. Clinics (Sao Paulo). Volume 76, 2021, e2830.
II. Jean J. C. The hydatidiform mole. Cell Adh Migr. 2016 Jan-Apr; 10(1-2): 226–235.
III. James L. N., Kenneth H. K., Ronald D. A. Abnormally low hCG in a complete hydatidiform molar pregnancy: The hook effect. Gynecol Oncol Case Rep. 2011 Dec; 1(1): 6–7.
IV. Nihal A. R., Marwa A. R., Thuriya A.H., Shaimaa A. S, Bushra Snand Moza A. K. Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes. Oman Med J. 2019 May; 34(3): 200–204.
V. Hoskins W. Principles and practice of gynecologic oncology. 4th ed. Williams L, Wilkins, editors. USA; 2005. 21-3.
VI. Triratmachat S, Nakaporntham P, etc. Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles. Asian Pacific Journal of Cancer Prevention, Vol 17, 2016.
VII. Syafii, Aprianti S, Hardjoeno. Kadar beta hCG penderita mola hidatidosa sebelum dan sesudah kuretase. Indones J Clin Pathol Med Lab. 2006;13(1):1-3.
VIII. Harjito VN, Hidayat YM, Amelia I. Hubungan antara karakteristik klinis pasien mola hidatidosa dengan performa reproduksi pascaevakuasi di rumah sakit hasan sadikin bandung. Dep Obstet dan Ginekol Fak Kedokt Univ Padjadjaran. 2017;3:26.
IX. Nodler JL, Kim KH, Alvarez RD. Abnormally low hCG in a complete hydatidiform molar pregnancy: The hook effect. Gynecol Oncol Case. 2011.
X. Hidayat YM, Gandamihardja S, Krisnadi SR. Hubungan kadar βHCG praevakuasi, gambaran histopatologi, dan kista lutein dengan performa βHCG pada penderita mola hidatidosa yang berkembang menjadi PTG dan kembali normal. Dep Obstet dan Ginekol Fak Kedokt Univ Padjadjaran. 2014;46:248.
XI. Manuaba. Buku ajar patologi obstetri. Jakarta: EGC; 2008. 86-7.
XII. Akbar N. D. S., Agustria Z. S., Patiyus A., Theodorus. Malignancy Risk Factors of Hydatidiform Mole. Indonesian Journal of Obstetrics and Gynecology. VOLUME 7 NO. 2 APRIL 2019.