Crohn's Disease in Adults for the Primary Care Physician
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Abstract
Crohn's disease is an inflammatory bowel disease of unclear etiology, associated with an excessive immune response with stages of remission and activation. It can affect the entire gastrointestinal tract from the mouth to the anus; the most frequent symptoms are abdominal pain and diarrhea. The impact that lifestyle modification and good treatment have on the patient's life is so crucial that primary care physicians must learn to recognize it and not confuse it with similar gastrointestinal pathologies.
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References
I. Loftus EV Jr. Update on the Incidence and Prevalence of Inflammatory Bowel Disease in the United States.. Gastroenterology & hepatology. 2016; 12(11): p.704-707. pmid: 28035199.
II. Feuerstein, Joseph D.; Cheifetz, Adam S. (2017). Crohn Disease: Epidemiology, Diagnosis, and Management. Mayo Clinic Proceedings, (), S0025619617303130–.
doi: 10.1016/j.mayocp.2017.04.010
III. Daniel C Baumgart; William J Sandborn (2012). Crohn's disease. , 380(9853), –. doi:10.1016/s0140-6736(12)60026-9
IV. Boyapati, Ray; Satsangi, Jack; Tzer Ho, Gwo (2015). Pathogenesis of Crohn's disease. F1000Prime Reports, 7(), –. doi:10.12703/P7-44
V. Veauthier B, Hornecker JR. Crohn's Disease: Diagnosis and Management. Am Fam Physician .2018; 98(11): p.661-669. pmid: 30485038.
VI. Frank Makowiec; Ekkehard C. Jehle; Horst -Dieter Becker; Michael Starlinger (1997). Perianal abscess in Crohn's disease., 40(4), 443–450.
doi:10.1007/bf02258390
VII. Levine JS, Burakoff R. Extraintestinal manifestations of inflammatory bowel disease.. Gastroenterology & hepatology .2011; 7(4): p.235-41. pmid: 21857821.
VIII. Vadstrup, Kasper; Alulis, Sarah; Borsi, Andras; Jørgensen, Tine Rikke; Nielsen, Agnete; Munkholm, Pia; Qvist, Niels (2020). Extraintestinal Manifestations and Other Comorbidities in Ulcerative Colitis and Crohn Disease: A Danish Nationwide Registry Study 2003â2016. Crohn's & Colitis 360, 2(3), otaa070–.
doi:10.1093/crocol/otaa070
IX. Andreas N. Kapsoritakis; Athanasios K. Psychos; Aekaterini Sfiridaki; Elias Zintzaras; Spiros P. Potamianos (2006). Finger clubbing and erythropoietin serum levels in active IBD. , 12(6), 535–536. doi:10.1097/00054725-200606000-00014
X. Lichtenstein, Gary R; Loftus, Edward V; Isaacs, Kim L; Regueiro, Miguel D; Gerson, Lauren B; Sands, Bruce E (2018). ACG Clinical Guideline: Management of Crohn’s Disease in Adults. The American Journal of Gastroenterology, (), –.
doi:10.1038/ajg.2018.27
XI. Spiceland CM, Lodhia N. Endoscopy in inflammatory bowel disease: Role in diagnosis, management, and treatment. World J Gastroenterol .2018; 24(35): p.4014-4020. doi: 10.3748/wjg. v24.i35.4014
XII. Kim, David H.; Chang, Kevin J.; Fowler, Kathryn J.; Cash, Brooks D.; Garcia, Evelyn M.; Kambadakone, Avinash R.; Levy, Angela D.; Liu, Peter S.; Mace, Sharon E.; Marin, Daniele; Moreno, Courtney; Peterson, Christine M.; Pietryga, Jason A.; Solnes, Lilja Bjork; Weinstein, Stefanie; Carucci, Laura R. (2020). ACR Appropriateness Criteria® Crohn Disease. Journal of the American College of Radiology, 17(5), S81–S99. doi: 10.1016/j.jacr.2020.01.030
XIII. Rameshshanker R. Endoscopy in inflammatory bowel disease when and why. World J Gastrointest Endosc .2012; 4(6): p.201. doi: 10.4253/wjge. v4.i6.201
XIV. Lee JM, Lee KM. Endoscopic Diagnosis and Differentiation of Inflammatory Bowel Disease. Clin Endoscop .2016; 49(4): p.370-5. doi: 10.5946/ce.2016.090
XV. Cushing K, Higgins PDR. Management of Crohn Disease. JAMA .2021; 325(1): p.69. doi: 10.1001/jama.2020.18936
XVI. Torres, Joana; Mehandru, Saurabh; Colombel, Jean-Frédéric; Peyrin-Biroulet, Laurent (2016). Crohn's disease. The Lancet, (), S0140673616317111–. doi:10.1016/S0140-6736(16)31711-1
XVII. Kredel, Lea I.; Siegmund, Britta (2014). Adipose-Tissue and Intestinal Inflammation –Visceral Obesity and Creeping Fat. Frontiers in Immunology, 5(), –.
doi:10.3389/fimmu.2014.00462
XVIII. Mitsuyama, Keiichi (2016). Antibody markers in the diagnosis of inflammatory bowel disease. World Journal of Gastroenterology, 22(3), 1304–. doi:10.3748/wjg. v22.i3.1304
XIX. Cappello, Maria; Morreale, Gaetano Cristian (2016). The Role of Laboratory Tests in Crohn's Disease. Clinical Medicine Insights: Gastroenterology, 9(), CGast.S38203–.
doi:10.4137/CGast.S38203
XX. Yan, Serena L. S.; Russell, Janice; Harris, Norman R.; Senchenkova, Elena Y.; Yildirim, Alper; Granger, D. Neil (2013). Platelet Abnormalities during Colonic Inflammation. Inflammatory Bowel Diseases, 19(6), 1245–1253.
doi:10.1097/mib.0b013e318281f3df
XXI. Timmermans, Wilhelmina Maria Cornelia; van Laar, Jan Alexander Michael; van Hagen, Petrus Martinus; van Zelm, Menno Cornelis (2016). Immunopathogenesis of granulomas in chronic autoinflammatory diseases. Clinical & Translational Immunology, 5(12), e118–. v5i11/8.php
doi:10.1038/cti.2016.75
XXII. Sulz, Michael Christian; Burri, Emanuel; Michetti, Pierre; Rogler, Gerhard; Peyrin-Biroulet, Laurent; Seibold, Frank (2020). Treatment Algorithms for Crohnâs Disease. Digestion, (), 1–15. doi:10.1159/000506364
XXIII. Feuerstein JD, Ho EY, Shmidt E, et al. AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease. Gastroenterology .2021; 160(7): p.2496-2508. doi: 10.1053/j.gastro.2021.04.022
XXIV. Lin MV, Blonski W, Lichtenstein GR. What is the optimal therapy for Crohn’s disease: step-up or top-down?. Expert Rev Gastroenterol Hepatol .2010; 4(2): p.167-180. doi: 10.1586/egh.10.4
XXV. Nakase H, Uchino M, Shinzaki S, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020. J Gastroenterol .2021; 56(6): p.489-526. doi: 10.1007/s00535-021-01784-1
XXVI. Xue CE, Shen QH, Wang Y, Zhang JY, Lin FR. [Clinical Significance of the Serum EPO Level in Patients with Iron Deficiency Anemia]. Zhongguo shi yan xue ye xue za zhi .2015; 23(5): p.1410-4. doi: 10.7534/j.issn.1009-2137.2015.05.036
XXVII. Docherty MJ, Jones RC 3rd, Wallace MS. Managing pain in inflammatory bowel disease.. Gastroenterol Hepatol .2011; 7(9): p.592-601.
pmid: 22298998
XXVIII. Shah SB, Hanauer SB. Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions.. Rev Gastroenterol Disord .2007; 7 Suppl 3: p.S3-10. pmid: 18192964
XXIX. Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
XXX. Adamina M, Bonovas S, Raine T, et al. ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment. Journal of Crohn's and Colitis .2019; 14(2): p.155-168.
doi: 10.1093/ecco-jcc/jjz187
XXXI. Makowiec F, Jehle EC, Becker H-D, Starlinger M. Perianal abscess in Crohnʼs disease. Diseases of the Colon & Rectum .1997; 40(4): p.443-450. doi: 10.1007/bf02258390