A Systematic Review of Procyanidins: Updates on Current Bioactivities and Potential Benefits in Wound Healing

Article Sidebar

PDF
Published: Aug 2, 2022
DOI: https://doi.org/10.47191/ijmscrs/v2-i8-01
Keywords:
human cell procyanidins systematic review wound healing

Main Article Content

Ferni
Department of Emergency, Purwokerto Orthopaedic Hospital, Central Java, Indonesia Plastic Surgery Intern, Department of Surgery, Faculty of Medicine, University of General Soedirman, Central Java, Indonesia
Clara Alverina
Department of Emergency, Brawijaya Military Hospital, East Java, Indonesia
Ahmad Fawzy Mas’ud
Plastic Reconstructive and Aesthetic Surgeon, Head of Department of Surgery, Faculty of Medicine, University of General Soedirman, Central Java, Indonesia

Abstract

Introduction: Procyanidins are a class of flavonoids found in many fruits and plants and have been used as traditional medicine or other homemade remedies, particularly for wound healing. This study systematically reviews the available literature on the potential benefits of procyanidins for wound healing in human cells.


Materials/Methods: Relevant keywords consisting of "Procyanidin" AND "Wound healing" was explored in databases including PubMed, Google Scholar, Nature, and Science Direct. This is a systematic review following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.


Results: Seven (7) articles met the established inclusion and exclusion criteria. Procyanidins presented a potential benefit in cellular proliferation and migration, antibacterial, anti-inflammatory, and antioxidant activity in wound healing.


Conclusion: Procyanidins are beneficial for developing therapies in wound healing, and our review provides a scientific basis for future research.

Article Details

How to Cite
Ferni, Alverina, C., & Ahmad Fawzy Mas’ud. (2022). A Systematic Review of Procyanidins: Updates on Current Bioactivities and Potential Benefits in Wound Healing. International Journal of Medical Science and Clinical Research Studies, 2(08), 718–723. https://doi.org/10.47191/ijmscrs/v2-i8-01
Issue
Vol. 2 No. 08 (2022): Volume 02 Issue 08 August 2022
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

References

I. Bitzer ZT, Glisan SL, Dorenkott MR, Goodrich KM, Ye L, O’Keefe SF, et al. Cocoa procyanidins with different degrees of polymerization possess distinct activities in models of colonic inflammation. J Nutr Biochem. 2015 Aug;26(8):827–31.

II. Dasiman R, Nor NM, Eshak Z, Mutalip SSM, Su-wandi NR, Bidin H. A review of procyanidin: Up-dates on current bioactivities and potential health benefits. Vol. 12, Biointerface Research in Applied Chemistry. AMG Transcend Association; 2022. p. 5918–40.

III. Cañedo-Dorantes L, Cañedo-Ayala M. Skin acute wound healing: A comprehensive review. Int J In-flam. 2019;2019.

IV. Gonzalez ACDO, Andrade ZDA, Costa TF, Medrado ARAP. Wound healing - A literature re-view. Vol. 91, Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia; 2016. p. 614–20.

V. Wilkinson HN, Hardman MJ. Wound healing: cel-lular mechanisms and pathological outcomes: Cel-lular Mechanisms of Wound Repair. Open Biol. 2020;10(9).

VI. Ziemlewska A, Zagórska-Dziok M, Nizioł-Łukaszewska Z. Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products. Sci Rep [Internet]. 2021;11(1):1–14. Available from: https://doi.org/10.1038/s41598-021-82207-2

VII. Van de Velde F, Esposito D, Grace MH, Pirovani ME, Lila MA. Anti-inflammatory and wound heal-ing properties of polyphenolic extracts from straw-berry and blackberry fruits. Food Res Int [Internet]. 2019;121:453–62. Available from:

https://doi.org/10.1016/j.foodres.2018.11.059

VIII. Esposito D, Overall J, Grace MH, Komarnytsky S, Lila MA. Alaskan Berry extracts promote dermal wound repair through modulation of bioenergetics and integrin signaling. Front Pharmacol. 2019;10(SEP):1–15.

IX. Kisseih E, Lechtenberg M, Petereit F, Sendker J, Zacharski D, Brandt S, et al. Phytochemical char-acterization and in vitro wound healing activity of leaf extracts from Combretum mucronatum Schum. & Thonn.: Oligomeric procyanidins as strong inductors of cellular differentiation. J Eth-nopharmacol. 2015;174:628–36.

X. Kim BJ, Park JK, Kim BK, Park SJ, Kim MK, Lee C won, et al. Oligomeric Procyanidins (OPCs) Inhibit Procollagen Type I Secretion of Fibroblasts. Tissue Eng Regen Med. 2017;14(3):297–306.

XI. Karakas FP, Turker AU, Karakas A, Mshvildadze V, Pichette A, Legault J. In vitro cytotoxic, antibac-terial, anti-inflammatory, and antioxidant activi-ties and phenolic content in wild-grown flowers of common daisy—A medicinal plant. J Herb Med [Internet]. 2017;8:31–9. Available from:

http://dx.doi.org/10.1016/j.hermed.2016.11.003

XII. Nie X, Tang W, Zhang Z, Yang C, Qian L, Xie X, et al. Procyanidin B2 mitigates endothelial endo-plasmic reticulum stress through a PPARδ-Dependent mechanism. Redox Biol. 2020;37:101728.