Diagnosis and Treatment of Osteoporosis, an Update Bibliographic Review

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Miriam Guadalupe Rodríguez Flores
Luis Humberto Martínez González
Jorge Alejandro Cruz Ponce
Juan Eduardo Espejo López
Carlos Marín Oliva
Isaac Montijo Ramírez
Abraham Azael Jaraleño Reyes

Abstract

Introduction: Osteoporosis is a chronic, progressive skeletal disease characterized by low bone mineral density and deterioration of bone structure. There are multiple risk factors, both modifiable and non-modifiable. The main complication is fractures, which is why it must be diagnosed early and in a timely manner.


Material and methods: Fourteen articles and one book on the diagnosis and treatment of osteoporosis were chosen in order to compare the best plan to follow in these patients in the different bibliographies reviewed.


Discussion: The gold standard for diagnosing osteoporosis is the measurement of bone density with the dual energy X-ray absorptiometry device, using the T-score. The use of different biomarkers is useful both for early diagnosis and for monitoring the reaction to treatment, but it is necessary to take into account that the main objective is to prevent the disease and to improve the quality of life of the patients. On the other hand, the main and early treatment consists of physical activity adapted to each patient, diet rich in calcium, magnesium and vitamins that promote bone health, the pharmacological part of the treatment has different areas that depends on the situation of each patient, considering gender such as estrogens and progestogens in postmenopausal women, tolerance to drugs such as Denosumab, and in general, bisphosphonate is used as the first line of treatment due to the increase in bone mineral density that it produces, helping to prevent fractures and improving the quality of life of each patient.


Conclusion: Osteoporosis is one of the diseases that can prevent the realization of basic activities, for this disease there are different methods of diagnosis and treatment, the main objective is to detect risk factors and make an early diagnosis to avoid complications that entails, relying on tools such as the FRAX calculator and the use of biomarkers, all this to reach the conclusion of the investigation, to use the different options and tools to provide appropriate treatment, this publication being an update on the options that are available today to treat this condition.

Article Details

How to Cite
Rodríguez Flores, M. G. ., Martínez González, L. H. ., Cruz Ponce, J. A., Espejo López, J. E. ., Oliva, C. M., Ramírez, I. M. ., & Jaraleño Reyes, A. A. . (2022). Diagnosis and Treatment of Osteoporosis, an Update Bibliographic Review. International Journal of Medical Science and Clinical Research Studies, 2(6), 544–551. https://doi.org/10.47191/ijmscrs/v2-i6-19
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References

I. Pope, R., & Doback, J. (2020, January 21). Osteoporosis Diagnosis and Management. Clinical Key. Retrieved April 14, 2022, from https://doi.org/10.1016/j.cpha.2020.09.009

II. Cameron, M., Austel, A., & Lie, J. (2018). Osteoporosis: A Review of Treatment Options. NIH.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768298/

III. Shanahan, J., Chueco, M., Serrano, H. Lopez, V. (2018). Harrison. Principles of Internal Medicine: Vol. 2° (20th ed.) Chapter 351. McGraw-Hill Education.

IV. Gómez, O., Talero A., Zanchetta, M., Madeira, M., Moreira, C., Campusano, C., Orjuela, A., Cerdas, S., Peña, M., Reza, A., Velazco, C., Mendoza, B., Uzcátegui, L. & Rueda, P.. (2021). Diagnostic, treatment, and follow-up of osteoporosis-position statement of the Latin American Federation of Endocrinology. International Osteoporosis Foundation and National Osteoporosis Foundation 2021, Vol. 1, pp. 1-15. April 10, 2022, From Springer from the Digital Library of the Autonomous University of Guadalajara Database.

V. Di Paola, M., Gatti, D., Viapiana, O., Cianferotti, L., Cavalli, L., Caffarelli, C., Conversano, F., Quarta, E., Pisani, P., Girasole, G., Giusti, A., Manfredini, M., Arioli, G., Maturi, M., Bianchi, G., Nuti, R., Gonnelli, S., Brandi, M., Muratore, M. & Rossini, M. (2018). Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck. Osteoporosis InternationalOsteoporosis International, Vol. 30, pp. 391-402. April 10, 2022, From Springer from the Digital Library of the Autonomous University of Guadalajara Database.

VI. Li, C., Sun, J., & Yu, L. (2022). Diagnostic value of calcaneal quantitative ultrasound in the evaluation of osteoporosis in middle-aged and elderly patients. Medicine, 101(2),

e28325.https://doi.org/10.1097/MD.0000000000028325.

VII. Salman, H. D. (2021, December 17). MiRNA-133a and MiRNA-25 3p and their relationship with some variables in serum of patients with Osteoporosis. Zenodo. Retrieved April 13, 2022, from https://zenodo.org/record/5788644

VIII. Sarah C. Goode, DNP, FNP-BC, Theresa F. Wright, DNP, RN, Colleen Lynch, DNP, RN (2019). Osteoporosis Screening and Treatment: A Collaborative Appr. 04/16/2022, from American Association of Nurse Practitioners Website: https://doi.org/10.1016/j.nurpra.2019.10.017

IX. Martiniakova, M., Babikova, M., Mondockova, V., Blahova, J., Kovacova, V., & Omelka, R. (2022). The role of macronutrients, micronutrients and flavonoid polyphenols in the prevention and treatment of osteoporosis. Nutrients, 14(3), 523. https://doi.org/10.3390/nu14030523.

X. Ringe, J. D. (2020). Plain vitamin D or active vitamin D in the treatment of osteoporosis: where do we stand today? Archives of Osteoporosis, 15(1). https://doi.org/10.1007/s11657-020-00842-0

XI. Papadakis, M. A., McPhee, S. J. Rabow, M. W. (2020). Clinical diagnosis and treatment: Vol. 1° (6th ed.). Mc.

XII. Casado, E., & Neyro, J. L. (2021). Sequential treatment in osteoporosis. New trends. Scielo. https://scielo.isciii.es/pdf/romm/v13n4/1889-836X-romm-13-4-0107.pdf

XIII. Bover, J., Ureña-Torres, P., Laiz Alonso, A. M., Torregrosa, J. V., Rodríguez-García, M., Castro-Alonso, C., Górriz, J. L., Benito, S., López-Báez, V., Lloret Cora, M. J., Cigarrán, S., DaSilva, I., Sánchez-Bayá, M., Mateu Escudero, S., Guirado, L., & Cannata-Andía, J. (2019). Osteoporosis, bone mineral density and CKD-MBD complex (II): therapeutic implications. Nephrology, 39(3), 227-242. https://doi.org/10.1016/j.nefro.2018.10.009.

XIV. Y. Wan, F. Zeng, H. Tan, Y. Lu, Y. Zhang, L. Zhao, R. You. (2022). Cost-effectiveness analyses of denosumab for osteoporosis: a systematic review. 16/04/2022, from International

Osteoporosis Foundation and National Osteoporosis Foundation Website:

https://doi.org/10.1007/s00198-021-06268-9

XV. Patricia Clark, Fernando Carlos Rivera, Lucía Méndez Sánchez, Carlos Fernando Mendoza Gutiérrez, Jessica Liliana Vargas Neri, Sandra Miriam Carrillo Vázquez, l Daniel Xavier Xibillé Friedmann, Ariana Alvarado Ceballos, José Manuel Aguilera Zepeda, Víctor Mercado Cárdenas, Hilario Ávila Amengolh,j. (January 4, 2019). Severe osteoporosis: Principles for pharmacological therapy in Mexico. Reumatología clínica, 2, 97-105. doi:

1016/j.reuma.2019.04.001.

XVI. Kenneth G. Saag, M.D., Jeffrey Petersen, M.D., Maria Luisa Brandi, M.D., Andrew C. Karaplis, M.D., Ph.D., Mattias Lorentzon, M.D., Ph.D., Thierry Thomas, M.D., Ph.D., Judy Maddox, D.O., Michelle Fan, Ph.D., Paul D. Meisner, Pharm.D., and Andreas Grauer, M.D. (October 12, 2017). Romosozumab or Alendronate for Fracture in Women with Osteoporosis. The New England Journal of Medicine, 377, 1417-1427. DOI: 10.1056/NEJMoa1708322.