Acute Myocardial Infarction in the Context of Diabetic Ketoacidosis: Pathophysiological Interactions, Clinical Manifestations, and Therapeutic Considerations

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Published: Oct 29, 2024
DOI: https://doi.org/10.47191/ijmscrs/v4-i10-39
Keywords:
Acute myocardial infarction, diabetic ketoacidosis, hyperglycemia, ketosis, metabolic acidosis, myocardial ischemia, cardiovascular complications, diabetes mellitus, ischemic heart disease, metabolic disturbances

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Donaldo Emiliano Silva López
Tecnológico de Monterrey Campus Monterrey, Nuevo Léon, Mexico.
Veronica Eloísa Durán Jiménez
Universidad Anahuac Cancún. Cancún, Quintana Roo, México
Nidia Carolina Córdova Hernández
Universidad del Valle de México campus Reynosa. Tamaulipas, México.
Geraldine Nieves Vázquez
Universidad de Guadalajara. Guadalajara, Jalisco, México.
María Elisa González Robles
Universidad de Guadalajara. Guadalajara, Jalisco, México.
Marian Anahí Rodríguez Carrillo
Universidad Autónoma de Aguascalientes. Aguascalientes, México.

Abstract

Acute myocardial infarction (AMI) and diabetic ketoacidosis (DKA) are two critical conditions that can coexist with significant morbidity and mortality. AMI is a leading cause of cardiovascular death, while DKA is a severe complication of uncontrolled diabetes mellitus, characterized by hyperglycemia, metabolic acidosis, and ketonemia. The convergence of these conditions presents unique challenges in diagnosis and management, as the metabolic disturbances of DKA can exacerbate myocardial ischemia and contribute to poor clinical outcomes. This article aims to explore the pathophysiological interplay between AMI and DKA, focusing on their shared risk factors, metabolic derangements, and the impact of hyperglycemia and ketosis on myocardial oxygen supply and demand. Furthermore, we discuss the clinical presentation, diagnostic strategies, and therapeutic approaches tailored to this dual pathology. Early recognition and prompt intervention are crucial to improving prognosis in patients with coexisting AMI and DKA. Multidisciplinary management involving cardiologists, endocrinologists, and intensivists is essential to mitigate the adverse outcomes of this complex clinical scenario.

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How to Cite
Donaldo Emiliano Silva López, Veronica Eloísa Durán Jiménez, Nidia Carolina Córdova Hernández, Geraldine Nieves Vázquez, María Elisa González Robles, & Marian Anahí Rodríguez Carrillo. (2024). Acute Myocardial Infarction in the Context of Diabetic Ketoacidosis: Pathophysiological Interactions, Clinical Manifestations, and Therapeutic Considerations. International Journal of Medical Science and Clinical Research Studies, 4(10), 1928–1937. https://doi.org/10.47191/ijmscrs/v4-i10-39
Issue
Vol. 4 No. 10 (2024): Volume 04 Issue 10 October 2024
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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