Overcoming Barriers: Diagnosis of High-Grade Melanoma: Perspective from a Clinical Case
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Abstract
We present the case of a 30-year-old male patient with loss of visual acuity in the left eye. The imaging study detected a lesion of high suspicion of tumor in the left eye. Enucleation of the left eye was performed, confirming the diagnosis of choroidal melanoma by histopathological study. Subsequently, the disease progressed with neoplastic activity in the lungs, liver, lymph nodes and central nervous system. A case description is provided along with a bibliographic review, focusing on the approach and prognostic factors in patients with metastatic disease.
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References
I. Singh P, Singh A. Choroidal melanoma. Vol. 5, Oman Journal of Ophthalmology. 2012. p. 3–9.
II. Soliman N, Mamdouh D, Elkordi A. Choroidal Melanoma: A Mini Review. Medicines. 2023 Jan 5;10(1):11.
III. Patiño-Calla K, Quezada G, Goicochea-Arévalo R. Choroidal melanoma: Case report and review of reports from Latin America. Gaceta Mexicana de Oncologia. 2022 Jul 1; 21:95–101.
IV. Di Luciano Andreas, Adaniya Agustina. Melanoma coroideo: revisión sistemática. Oftalmol Clin Exp. 2020; 13:68–81.
V. Wolfe GS. Choroidal Melanoma: A case report and updated review of new diagnostic tests and treatments [Internet]. Article in Optometry-Journal of the American Optometric Association. 2012. Available from:
https://www.researchgate.net/publication/273460404
VI. Bai H, Bosch JJ, Heindl LM. Current management of uveal melanoma: A review. Vol. 51, Clinical and Experimental Ophthalmology. John Wiley and Sons Inc; 2023. p. 484–94.
VII. Rodriguez-Vidal C, Fernandez-Diaz D, Fernandez-Marta B, Lago-Baameiro N, Pardo M, Silva P, et al. Treatment of metastatic uveal melanoma: Systematic review. Vol. 12, Cancers. MDPI AG; 2020. p. 1–22.
VIII. Karz A, Dimitrova M, Kleffman K, Alvarez-Breckenridge C, Atkins MB, Boire A, et al. Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities. Vol. 35, Pigment Cell and Melanoma Research. John Wiley and Sons Inc; 2022. p. 554–72.
IX. Patel SP, Katz SC. Novel treatment paradigms for metastatic uveal melanoma. Vol. 29, Cancer Gene Therapy. Springer Nature; 2022. p. 1807–8.
X. Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, et al. Systemic Therapy for Melanoma: ASCO Guideline Update. Journal of Clinical Oncology. 2023 Oct 20;41(30):4794–820.
XI. Fernandes AG, Tavares JHC, Branco AMC, Morales MC, Belfort Neto R. Choroidal melanoma tumor profile and treatment pattern for newly diagnosed patients at a reference public hospital in Sao Paulo, Brazil. BMC Ophthalmol. 2022 Dec 1;22(1).
XII. Koch EAT, Heppt M V., Berking C. The Current State of Systemic Therapy of Metastatic Uveal Melanoma. Am J Clin Dermatol. 2024 Sep 1;
XIII. Told R, Kreminger J, Schmidt-Erfurth U, Dunavoelgyi R, Reumueller A. Impact of Choroidal Melanoma Characteristics on Progression-Free Survival in Patients Undergoing Hypofractionated Stereotactic Photon Radiotherapy. Ophthalmol Ther. 2023 Dec 1;12(6):3039–46.
XIV. Śniegocki M, Smuczyński W, Woźniak-Dąbrowska K, Nowacka A. Brain metastasis from ocular malignant melanoma: A case report of a brain secondary lesion occurring 5 years after the primary lesion treatment. Vol. 36, Postepy Dermatologii i Alergologii. Termedia Publishing House Ltd.; 2019. p. 371–3.
XV. Rutkowski P, Kiprian D, Świtaj T, Michalik R, Spałek M, Kozak K, et al. Management of melanoma central nervous system metastases. Vol. 20, Oncology in Clinical Practice. Via Medica; 2024. p. 161–74.
XVI. Sharma D, Hamilton J. Choroidal Melanoma in an Asymptomatic Patient. CRO (Clinical & Refractive Optometry) Journal. 2023 Feb 10.
XVII. Alberto Fernández Soler J, Enrique Fuentes Hidalgo J, Orges Ramírez M, Martínez Quintana S, Serrano Fuentes T. CORREO CIENTÍFICO MÉDICO DE HOLGUÍN Melanoma maligno de coroides: a propósito de un caso Choroidal malignant melanoma: a case report.