Oseltamivir-Induced Steven Johnson Syndrome, Case Report

Abstract

First described in 1922, Steven Johnson Syndrome (SJS) is an acute mucocutaneous disease with conjunctivitis, stomatitis, purple macules and skin necrosis in which an acute inflammatory process followed by the action of immune complexes has been identified. In the middle hypersensitivity, it should involve less than 10% of the total body surface. Its annual incidence in the world is unknown, it is estimated 1-2 cases per million in a year of which 20% will be pediatric patients; this can be triggered by drugs, infectious agents and biological agents. It manifests as lesions in the skin and mucous membranes of which it can involve ocular conjunctiva, oral, nasal, vaginal, urethral and perianal mucosa