Multifocal Epithelioid Hemangioendothelioma – A Case Report
Main Article Content
Abstract
Epithelioid hemangioendotheliomas are rare neoplasms involving any sites including soft tissue, lung, liver, kidney, etc. and many more. A multifocal hemangioendothelioma is extremely rare, and it can very well be mistaken as angiosarcoma with metastasis. Here, we describe a case of multifocal hemangioendothelioma which radiologically appeared like multiple metastatic lesions in paraspinal muscle, liver, kidney, adrenal, lung and gluteus muscle arising from renal cell carcinoma, lung carcinoma, or renal angiosarcoma. But histologically the picture is characteristic of epithelioid hemangioendothelioma. Morphological differentiation between an epithelioid hemangioendothelioma and epithelioid angiosarcoma is more helpful than the immunohistochemical markers.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Rosenbaum E, Jadeja B, Xu B, Zhang L, Agaram NP, Travis W, Singer S, Tap WD, Antonescu CR. Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. Mod Pathol. 2020 Apr;33(4):591-602.
doi: 10.1038/s41379-019-0368-8. Epub 2019 Sep 19. PMID: 31537895; PMCID: PMC7228463.
Giardino A, Miller FH, Kalb B, Ramalho M, Martin DR, Rodacki K, Woosley JT, Semelka RC. Hepatic epithelioid hemangioendothelioma: a report from three university centers. Radiol Bras. 2016 Sep-Oct;49(5):288-294. doi: 10.1590/0100-3984.2015. 0059. PMID: 27818541; PMCID: PMC5094816.
Sardaro A, Bardoscia L, Petruzzelli MF, Portaluri M. Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor. Oncol Rev. 2014 Oct 13;8(2):259. doi: 10.4081/oncol.2014.259. PMID: 25992243; PMCID: PMC4419652.
Taniai T, Onda S, Sato S, Shiba H, Sakamoto T, Yanaga K. Hepatic Epithelioid Hemangioendothelioma: Difficult Differential Diagnosis from Angiosarcoma. Case Rep Gastroenterol. 2020 Jan 29;14(1):56-62. doi: 10.1159/000505513. PMID: 32110201; PMCID: PMC7036556.
Sardaro A, Bardoscia L, Petruzzelli MF, Portaluri M. Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor. Oncol Rev. 2014 Oct 13;8(2):259. doi: 10.4081/oncol.2014.259. PMID: 25992243; PMCID: PMC4419652.
Wu X, Li B, Zheng C, Hong T, He X. Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study. Eur J Med Res. 2019 Feb 28;24(1):16. doi: 10.1186/s40001-019-0375-8. PMID: 30819247; PMCID: PMC6394028.
Mentzel T, Beham A, Calonje E, Katenkamp D, Fletcher CD. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol. 1997 Apr;21(4):363-74.
doi: 10.1097/00000478-199704000-00001. PMID: 9130982.
Doyle, L.A. (2014), Sarcoma classification: An update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone. Cancer, 120: 1763-1774. https://doi.org/10.1002/cncr.28657
Sirikulchayanonta V, Jinawath A, Jaovisidha S. Epithelioid hemangioma involving three contiguous bones: a case report with a review of the literature. Korean J Radiol. 2010 Nov-Dec;11(6):692-6. doi: 10.3348/kjr.2010.11.6.692. Epub 2010 Oct 29. PMID: 21076597; PMCID: PMC2974233.
Doyle LA, Fletcher CD, Hornick JL. Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics. Am J Surg Pathol. 2016 Jan;40(1):94-102. doi: 10.1097/PAS.0000000000000511.
PMID: 26414223.
Flucke, U., Vogels, R.J., de Saint Aubain Somerhausen, N. et al. Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol 9, 131 (2014). https://doi.org/10.1186/1746-1596-9-131
Lotfalla MM, Folpe AL, Fritchie KJ, Greipp PT, Galliano GG, Halling KC, Mounajjed T, Torres-Mora J, Graham RP. Hepatic YAP1-TFE3 Rearranged Epithelioid Hemangioendothelioma. Case Rep Gastrointest Med. 2019 Jun 23;2019:7530845. doi: 10.1155/2019/7530845. PMID: 31341686; PMCID: PMC6612390.
Taniai T, Onda S, Sato S, Shiba H, Sakamoto T, Yanaga K. Hepatic Epithelioid Hemangioendothelioma: Difficult Differential Diagnosis from Angiosarcoma. Case Rep Gastroenterol. 2020 Jan 29;14(1):56-62. doi: 10.1159/000505513. PMID: 32110201; PMCID: PMC7036556.