The Potential Therapeutic Role of Flavonoids and Mangiferin in Mango Peel for Burn Wound Healing: A Comprehensive Literature Review
Main Article Content
Abstract
Background: Approximately 11 million burn injuries occur worldwide each year, causing significant morbidity and emotional distress. Burn wounds heal slowly, impacting quality of life. Mango peel contains flavonoids and mangiferin, which may aid burn wound healing.
Objectives: This literature review aims to explore flavonoids and mangiferin in mango peel for burn wound healing.
Methods: We searched PubMed, Google Scholar, Scopus, and Web of Science using keywords like burn wound, thermal injuries, flavonoid, mangiferin, and mango peel. We included accessible articles in Bahasa Indonesia or English, including research articles, systematic reviews, meta-analyses, and literature reviews.
Discussion: Flavonoids enhance collagen synthesis and increase fibroblast basic growth factor and vascular endothelial growth factor, promoting granulation tissue formation. Mangiferin has anti-inflammatory properties, suppressing COX-1, COX-2, and PGE-2 production, and deactivating the NLRP3 inflammasome. These actions suggest potential for improving burn wound healing.
Conclusion: Flavonoids and mangiferin in mango peel show promise for wound healing due to their anti-inflammatory, antibacterial properties, and ability to stimulate collagen and VEGF formation. Further research is needed for clinical application and better outcomes.
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References
I. Lebaka VR, Wee YJ, Ye W, Korivi M. Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit. Int J Environ Res Public Health. 2021 Jan 16;18(2):741.
II. Güldoğan CE, Kendirci M, Gündoğdu E, Yastı AÇ. Analysis of factors associated with mortality in major burn patients. Turk J Surg. 2019 Sep;35(3):155–64.
III. Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020 Feb 13;6(1):11.
IV. Golebiewska EM, Poole AW. Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev. 2015 May;29(3):153–62.
V. Chen L, DiPietro LA. Toll-Like Receptor Function in Acute Wounds. Adv Wound Care (New Rochelle). 2017 Oct;6(10):344–55.
VI. Scully D, Sfyri P, Wilkinson HN, Acebes‐Huerta A, Verpoorten S, Muñoz‐Turrillas MC, et al. Optimising platelet secretomes to deliver robust tissue‐specific regeneration. J Tissue Eng Regen Med. 2020 Jan 11;14(1):82–98.
VII. Tiwari VK. Burn wound: How it differs from other wounds? Indian Journal of Plastic Surgery. 2012 May 27;45(02):364–73.
VIII. Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020 Sep 30;10(9).
IX. Segel GB, Halterman MW, Lichtman MA. The paradox of the neutrophilˈs role in tissue injury. J Leukoc Biol. 2011 Mar;89(3):359–72.
X. Das A, Sinha M, Datta S, Abas M, Chaffee S, Sen CK, et al. Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration. Am J Pathol. 2015 Oct;185(10):2596–606.
XI. Campbell L, Saville CR, Murray PJ, Cruickshank SM, Hardman MJ. Local Arginase 1 Activity Is Required for Cutaneous Wound Healing. Journal of Investigative Dermatology. 2013 Oct;133(10):2461–70.
XII. Lucas T, Waisman A, Ranjan R, Roes J, Krieg T, Müller W, et al. Differential Roles of Macrophages in Diverse Phases of Skin Repair. The Journal of Immunology. 2010 Apr 1;184(7):3964–77.
XIII. Matus CE, Bhoola KD, Figueroa CD. Kinin B1 Receptor Signaling in Skin Homeostasis and Wound Healing. Yale J Biol Med. 2020 Mar;93(1):175–85.
XIV. Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, et al. Epithelialization in Wound Healing: A Comprehensive Review. Adv Wound Care (New Rochelle). 2014 Jul;3(7):445–64.
XV. Foncerrada G, Capek KD, Herndon DN, Lee JO, Sirvent RZ, Finnerty CC. The state of the art on burn wound healing. J. Avid Sci. 2017:4-52.
XVI. Xue M, Jackson CJ. Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring. Adv Wound Care (New Rochelle). 2015 Mar;4(3):119–36.
XVII. Broughton G, Janis JE, Attinger CE. The Basic Science of Wound Healing. Plast Reconstr Surg. 2006 Jun;117(SUPPLEMENT):12S-34S.
XVIII. Nguyen TT, Mobashery S, Chang M. Roles of Matrix Metalloproteinases in Cutaneous Wound Healing. In: Wound Healing - New insights into Ancient Challenges. InTech; 2016.
XIX. Suhatri S, Fidiyani D, Azzahra N, Suardi M. Effectiveness of Mango Leaf Extract (Mangifera indica L) on Healing of Second Level Cut Wound in Male White Mice (Mus musculus). JURNAL KESEHATAN TERAPAN. 2022 Jul 18;9(2):7–12.
XX. Marçal S, Pintado M. Mango peels as food ingredient / additive: nutritional value, processing, safety and applications. Trends Food Sci Technol. 2021 Aug;114:472–89.
XXI. Sardi VF, Astika A, Jalius IM, Ismed F. Quantification of Mangiferin from the Bioactive Fraction of Mango Leaves (Mangifera indica L.) and Evaluation of Wound-Healing Potential. Jordan Journal of Pharmaceutical Sciences. 2023 Sep 23;16(3):595–606.
XXII. Vithana MD, Singh Z, Johnson SK. Regulation of the levels of health promoting compounds: lupeol, mangiferin and phenolic acids in the pulp and peel of mango fruit: a review. J Sci Food Agric. 2019 Jun 29;99(8):3740–51.
XXIII. Anand Swaroop, Manashi Bagchi, Hiroyoshi Moriyama, Debasis Bagchi. Health Benefits of Mango (Mangifera Indica L) and Mangiferin. Jpn J Med (Lond). 2018;1(2):149–54.
XXIV. Badan Pusat Statistik. Produksi Tanaman Buah-buahan, 2021-2022. https://www.bps.go.id/id/statistics-table/2/NjIjMg==/produksi-tanaman-buah-buahan.html. 2023.
XXV. Sánchez-Mesa N, Sepúlveda-Valencia JU, Ciro-Velásquez HJ, Meireles MA. Bioactive compounds from mango peel (Mangifera indica l. var. Tommy atkins) obtained by supercritical fluids and pressurized liquids extraction. Rev Mex Ing Quim. 2019 Aug 1;19(2):755–67.
XXVI. Quintana SE, Salas S, García‐Zapateiro LA. Bioactive compounds of mango (Mangifera indica): a review of extraction technologies and chemical constituents. J Sci Food Agric. 2021 Dec 11;101(15):6186–92.
XXVII. Wongkaew M, Chaimongkol P, Leksawasdi N, Jantanasakulwong K, Rachtanapun P, Seesuriyachan P, et al. Mango Peel Pectin: Recovery, Functionality and Sustainable Uses. Polymers (Basel). 2021 Nov 11;13(22):3898.
XXVIII. Aslam MS, Ahmad MS, Riaz H, Raza SA, Hussain S, Qureshi OS, Maria P, Hamzah Z, Javed O. Role of flavonoids as wound healing agent. Phytochemicals-source of antioxidants and role in disease prevention. 2018 Nov 7;10:57353.
XXIX. Espinosa-Espinosa L, Garduño-Siciliano L, Rodriguez-Canales M, Hernandez-Portilla LB, Canales-Martinez MM, Rodriguez-Monroy MA. The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model. Molecules. 2022 Jan 1;27(1):259.
XXX. Ajila CM, Prasada Rao UJS. Mango peel dietary fibre: Composition and associated bound phenolics. J Funct Foods. 2013 Jan;5(1):444–50.
XXXI. Zulkefli N, Che Zahari CNM, Sayuti NH, Kamarudin AA, Saad N, Hamezah HS, et al. Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective. Int J Mol Sci. 2023 Feb 27;24(5):4607.
XXXII. Katike Umamahesh, Seelam Naga Sivudu, Obulam Vijaya Sarathi Reddy. Evaluation of antioxidant activity, total phenolics and total flavonoids in peels of five cultivars of mango (Mangifera indica) fruit. Journal of Medicinal Plants Studies. 2016;4(2):200–3.
XXXIII. Vyas, K. Syeda, A. Ahmad, S. Padhye, F.H. Sarkar. Perspectives on Medicinal Properties of Mangiferin. Mini-Reviews in Medicinal Chemistry. 2012;12:412–25.
XXXIV. Loan NTT, Long DT, Yen PND, Hanh TTM, Pham TN, Pham DTN. Purification Process of Mangiferin from Mangifera indica L. Leaves and Evaluation of Its Bioactivities. Processes. 2021 May 12;9(5):852.
XXXV. Barreto JC, Trevisan MTS, Hull WE, Erben G, de Brito ES, Pfundstein B, et al. Characterization and Quantitation of Polyphenolic Compounds in Bark, Kernel, Leaves, and Peel of Mango ( Mangifera indica L.). J Agric Food Chem. 2008 Jul 1;56(14):5599–610.
XXXVI. Kumar S, Pandey AK. Chemistry and Biological Activities of Flavonoids: An Overview. The Scientific World Journal. 2013;2013:1–16.
XXXVII. El-Nashar HAS, El-labbad EM, Al-Azzawi MA, Ashmawy NS. A New Xanthone Glycoside from Mangifera indica L.: Physicochemical Properties and In Vitro Anti-Skin Aging Activities. Molecules. 2022 Apr 19;27(9):2609.
XXXVIII. Che Zain MS, Lee SY, Sarian MN, Fakurazi S, Shaari K. In Vitro Wound Healing Potential of Flavonoid C-Glycosides from Oil Palm (Elaeis guineensis Jacq.) Leaves on 3T3 Fibroblast Cells. Antioxidants. 2020 Apr 17;9(4):326.
XXXIX. Choi S, Yoon M, Choi KY. Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt/β-Catenin Pathway. Adv Wound Care (New Rochelle). 2022 Feb 1;11(2):70–86.
XL. Carvalho MTB, Araújo-Filho HG, Barreto AS, Quintans-Júnior LJ, Quintans JSS, Barreto RSS. Wound healing properties of flavonoids: A systematic review highlighting the mechanisms of action. Phytomedicine. 2021 Sep;90:153636.
XLI. Emiroglu G, Ozergin Coskun Z, Kalkan Y, Celebi Erdivanli O, Tumkaya L, Terzi S, et al. The Effects of Curcumin on Wound Healing in a Rat Model of Nasal Mucosal Trauma. Evidence-Based Complementary and Alternative Medicine. 2017;2017:1–6.
XLII. Hamdy AAEMM, Ibrahem MAEM. Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial. J Contemp Dent Pract. 2010 Jul;11(4):9–16.
XLIII. Gallelli G, Cione E, Serra R, Leo A, Citraro R, Matricardi P, et al. Nano‐hydrogel embedded with quercetin and oleic acid as a new formulation in the treatment of diabetic foot ulcer: A pilot study. Int Wound J. 2020 Apr 25;17(2):485–90.
XLIV. Limsitthichaikoon S, Khampaenjiraroch B, Damrongrungruang T, Limphirat W, Thapphasaraphong S, Priprem A. Topical oral wound healing potential of anthocyanin complex: animal and clinical studies. Ther Deliv. 2018 May;9(5):359–74.
XLV. Damrongrungruang T, Paphangkorakit J, Limsitthichaikoon S, Khampaenjiraroch B, Davies MJ, Sungthong B, et al. Anthocyanin complex niosome gel accelerates oral wound healing: In vitro and clinical studies. Nanomedicine. 2021 Oct;37:102423.
XLVI. Lwin OM, Giribabu N, Kilari EK, Salleh N. Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats. Journal of Dermatological Treatment. 2021 Nov 17;32(8):1039–48.
XLVII. Subramanian S, Duraipandian C, Alsayari A, Ramachawolran G, Wong LS, Sekar M, et al. Wound healing properties of a new formulated flavonoid-rich fraction from Dodonaea viscosa Jacq. leaves extract. Front Pharmacol. 2023 Feb 2;14.
XLVIII. Sardi VF, Astika A, Jalius IM, Ismed F. Quantification of Mangiferin from the Bioactive Fraction of Mango Leaves (Mangifera indica L.) and Evaluation of Wound-Healing Potential. Jordan Journal of Pharmaceutical Sciences. 2023 Sep 23;16(3):595–606.