The Negative Impact of Vaping and Electric Cigarettes for Healing of Acute Wounds: A Literature Review

Main Article Content

Machfira Bulantrisna
Ahmad Fawzy

Abstract

Emerging evidence suggests that vaping can significantly impede wound healing, with prevalence rates of current e-cigarette use varying between 3.3% and 11.8%. This study aims to investigate the impact of vaping on wound healing, particularly in acute wounds encountered in plastic surgery settings. Electronic cigarettes (e-cigarettes), comprising a rechargeable battery and an atomizer or heating element, typically contain flavored liquids with or without nicotine as humectants. Skin wounds heal through overlapping inflammatory, proliferative, and remodeling phases. Chemical constituents of e-cigarettes, including propylene glycol (PG), vegetable glycerin (VG), nicotine, flavoring agents, and contaminants, hinder wound healing by inducing osmotic effects, cellular toxicity, vasoconstriction, reduced oxygen supply, impaired angiogenesis, cytotoxicity, and modulation of inflammatory responses. Similar to conventional cigarettes, e-cigarettes may compromise wound healing through a multifaceted mechanism, although they may offer a comparatively less harmful alternative.

Article Details

How to Cite
Bulantrisna, M., & Fawzy, A. . (2024). The Negative Impact of Vaping and Electric Cigarettes for Healing of Acute Wounds: A Literature Review. International Journal of Medical Science and Clinical Research Studies, 4(05), 940–945. https://doi.org/10.47191/ijmscrs/v4-i05-27
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Articles

References

I. Wipfli H, Samet JM. One hundred years in the making: The global tobacco epidemic. Annual Review of Public Health. 2016 Mar 18;37(1):149–66. doi:10.1146/annurev-publhealth-032315-021850

II. Yamamoto N, Kiyosawa T. Histological effects of occlusive dressing on healing of incisional skin wounds. International Wound Journal. 2012 Dec 21;11(6):616–21. doi:10.1111/iwj.12016

III. Hiemstra PS, Bals R. Basic science of electronic cigarettes: Assessment in cell culture and in vivo models. Respiratory Research. 2016 Oct 7;17(1). doi:10.1186/s12931-016-0447-z

IV. Jane Ling MY, Abdul Halim AF, Ahmad D, Ahmad N, Safian N, Mohammed Nawi A. Prevalence and associated factors of e-cigarette use among adolescents in Southeast Asia: A systematic review. International Journal of Environmental Research and Public Health. 2023 Feb 22;20(5):3883. doi:10.3390/ijerph20053883

V. Fracol M, Dorfman R, Janes L, Kulkarni S, Bethke K, Hansen N, et al. The surgical impact of e-cigarettes: A case report and review of the current literature. Archives of Plastic Surgery. 2017 Nov;44(06):477–81. doi:10.5999/aps.2017.00087

VI. Marques P, Piqueras L, Sanz M-J. An updated overview of e-cigarette impact on human health. Respiratory Research. 2021 May 18;22(1). doi:10.1186/s12931-021-01737-5

VII. Rowell TR, Tarran R. Will chronic e-cigarette use cause lung disease? American Journal of Physiology-Lung Cellular and Molecular Physiology. 2015 Dec 15;309(12). doi:10.1152/ajplung.00272.2015

VIII. Herrington JS, Myers C. Electronic Cigarette Solutions and resultant aerosol profiles. Journal of Chromatography A. 2015 Oct;1418:192–9. doi:10.1016/j.chroma.2015.09.034

IX. Schober W, Szendrei K, Matzen W, Osiander-Fuchs H, Heitmann D, Schettgen T, et al. Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. International Journal of Hygiene and Environmental Health. 2014 Jul;217(6):628–37. doi:10.1016/j.ijheh.2013.11.003

X. Rubinstein ML, Delucchi K, Benowitz NL, Ramo DE. Adolescent exposure to toxic volatile organic chemicals from e-cigarettes. Pediatrics. 2018 Apr 1;141(4). doi:10.1542/peds.2017-3557

XI. Mishra A, Chaturvedi P, Datta S, Sinukumar S, Joshi P, Garg A. Harmful effects of nicotine. Indian Journal of Medical and Paediatric Oncology. 2015 Jan;36(01):24–31. doi:10.4103/0971-5851.151771

XII. Hutzler C, Paschke M, Kruschinski S, Henkler F, Hahn J, Luch A. Chemical hazards present in liquids and vapors of electronic cigarettes. Archives of Toxicology. 2014 Jun 11;88(7):1295–308. doi:10.1007/s00204-014-1294-7

XIII. Pokhrel P, Herzog TA, Muranaka N, Fagan P. Young adult e-cigarette users’ reasons for liking and not liking e-cigarettes: A qualitative study. Psychology & Health. 2015 Jul 15;30(12):1450–69. doi:10.1080/08870446.2015.1061129

XIV. Williams M, Bozhilov K, Ghai S, Talbot P. Elements including metals in the atomizer and aerosol of disposable electronic cigarettes and electronic hookahs. PLOS ONE. 2017 Apr 17;12(4). doi:10.1371/journal.pone.0175430

XV. Heng MC. Wound healing in adult skin: Aiming for perfect regeneration. International Journal of Dermatology. 2011 Aug 19;50(9):1058–66. doi:10.1111/j.1365-4632.2011.04940.x

XVI. Demidova-Rice TN, Hamblin MR, Herman IM. Acute and impaired wound healing. Advances in Skin & Wound Care. 2012 Jul;25(7):304–14. doi:10.1097/01.asw.0000416006.55218.d0

XVII. Wang P-H, Huang B-S, Horng H-C, Yeh C-C, Chen Y-J. Wound healing. Journal of the Chinese Medical Association. 2018 Feb;81(2):94–101. doi:10.1016/j.jcma.2017.11.002

XVIII. Reinke JM, Sorg H. Wound repair and regeneration. European Surgical Research. 2012;49(1):35–43. doi:10.1159/000339613

XIX. Li B, Wang JH-C. Fibroblasts and myofibroblasts in wound healing: Force generation and measurement. Journal of Tissue Viability. 2011 Nov;20(4):108–20. doi:10.1016/j.jtv.2009.11.004

XX. Daynard R. Public health consequences of e-cigarettes: A Consensus Study Report of the National Academies of Sciences, Engineering, and medicine. Journal of Public Health Policy. 2018 Jul 5;39(3):379–81. doi:10.1057/s41271-018-0132-1

XXI. Barrington-Trimis JL, Urman R, Leventhal AM, Gauderman WJ, Cruz TB, Gilreath TD, et al. E-cigarettes, cigarettes, and the prevalence of adolescent tobacco use. Pediatrics. 2016 Aug 1;138(2). doi:10.1542/peds.2015-3983

XXII. Kowitt S, Meernik C, Baker H, Osman A, Huang L-L, Goldstein A. Perceptions and experiences with flavored non-menthol tobacco products: A systematic review of qualitative studies. International Journal of Environmental Research and Public Health. 2017 Mar 23;14(4):338. doi:10.3390/ijerph14040338

XXIII. Alanazi H, Semlali A, Chmielewski W, Rouabhia M. E-cigarettes increase candida albicans growth and modulate its interaction with gingival epithelial cells. International Journal of Environmental Research and Public Health. 2019 Jan 21;16(2):294. doi:10.3390/ijerph16020294

XXIV. Shaikh ZN, Alqahtani A, Almela T, Franklin K, Tayebi L, Moharamzadeh K. Effects of electronic cigarette liquid on monolayer and 3D tissue-engineered models of human gingival mucosa. Journal of Advanced Periodontology & Implant Dentistry. 2019 Dec 18;11(2):54–62. doi:10.15171/japid.2019.010

XXV. Ralho A, Coelho A, Ribeiro M, Paula A, Amaro I, Sousa J, et al. Effects of electronic cigarettes on oral cavity: A systematic review. Journal of Evidence Based Dental Practice. 2019 Dec;19(4):101318. doi:10.1016/j.jebdp.2019.04.002

XXVI. Willershausen I, Wolf T, Weyer V, Sader R, Ghanaati S, Willershausen B. Influence of e-smoking liquids on human periodontal ligament fibroblasts. Head & Face Medicine. 2014 Sept 15;10(1). doi:10.1186/1746-160x-10-39

XXVII. Rau AS, Reinikovaite V, Schmidt EP, Taraseviciene-Stewart L, Deleyiannis FW-B. Electronic cigarettes are as toxic to skin flap survival as tobacco cigarettes. Annals of Plastic Surgery. 2017 Jul;79(1):86–91. doi:10.1097/sap.0000000000000998

XXVIII. Troiano C, Jaleel Z, Spiegel JH. Association of electronic cigarette vaping and cigarette smoking with decreased random flap viability in rats. JAMA Facial Plastic Surgery. 2019 Jan;21(1):5–10. doi:10.1001/jamafacial.2018.1179

XXIX. Sørensen, L. T. Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review. Annals of surgery. 255(6):1069–79.

XXX. Krishnan NM, Han KD, Nahabedian MY. Can e-cigarettes cause free flap failure? A case of arterial vasospasm induced by electronic cigarettes following microsurgical breast reconstruction. Plastic and Reconstructive Surgery - Global Open. 2016 Jan;4(1). doi:10.1097/gox.0000000000000576

XXXI. Chen I, Todd I, Fairclough LC. Immunological and pathological effects of electronic cigarettes. Basic & Clinical Pharmacology & Toxicology. 2019 May 7;125(3):237–52. doi:10.1111/bcpt.13225

XXXII. Thieman T, Westmark D, Sutton A. Electronic cigarettes and Cutaneous Wound Healing: A systematic review. Journal of the American Academy of Dermatology. 2023 Apr;88(4):911–2. doi:10.1016/j.jaad.2022.10.042