The Impact of Advanced Reproductive Medicine on Female Fertility: Clinical and Technological Perspectives
Main Article Content
Abstract
Background: Infertility is defined as failure to be pregnant after 12 months of unprotected intercourse. This condition affects millions of individuals worldwide. It is not only a personal problem, causing stress and anxiety amongst individuals and couples, but it has become a community issue. One in every 6 couples will experience infertility in their lifetime. It is affecting both male and female reproductive systems, with causes ranging from hormonal imbalances to obstructive disorders. Despite its prevalence, fertility care is unequal and, for those in low and middle-income countries, virtually non-existent and a long overdue topic for global attention and action.
Method: We followed a systematic approach to select articles related to recent developments in female fertility and reproductive medicine. Keywords such as “female fertility” and “advanced reproductive medicine” were used for getting targeted articles. We used only peer-reviewed articles published from 2019 to 2024. Only high-quality data was extracted for general public information.
Result: Our findings show that Assisted Reproductive Technologies (ART), microfluidic devices, and innovations like CoQ10 therapies have significantly improved fertility treatment outcomes. AI-driven personalized medicine has enhanced accessibility and effectiveness, democratizing fertility care. Stem cell therapy and platelet-rich plasma techniques are another breakthrough in reproductive medicine.
Conclusion: It is concluded that medical advancements have revolutionized reproductive medicine. There is now a ray of new hope for those couple who are experiencing infertility. The future promises further improvements in success rates and patient experience with continued progress.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
I. World Health Organization: WHO. Infertility [Internet]. 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/infertility
II. Walker MH, Tobler KJ. Female infertility [Internet]. StatPearls - NCBI Bookshelf. 2022. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK556033/
III. News-Medical. The Effect of Anti-Inflammatories on ovulation [Internet]. News-Medical. 2022. Available from: https://www.news-medical.net/health/The-Effect-of-Anti-Inflammatories-on-Ovulation.aspx
IV. Emokpae MA, Brown SI. Effects of lifestyle factors on fertility: practical recommendations for modification. Reproduction & Fertility [Internet]. 2021 Jan 8;2(1):R13–26. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812443/
V. Sharma A, Shrivastava D. Psychological problems related to infertility. Cureus [Internet]. 2022 Oct 15; Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661871/
VI. Fertility drugs [Internet]. WebMD. 2000. Available from: https://www.webmd.com/infertility-and-reproduction/fertility-drugs
VII. Mohapatra R, Dash SK, Padhy S. Ethnobiological Studies from Manusmruti: IX. Niyoga Prathaa, A Natural Process of Artificial Insemination. Journal of Human Ecology [Internet]. 2001 Jan 1;12(1):33–8. Available from:
VIII. What infertility treatments are available? [Internet]. https://www.nichd.nih.gov/. 2017. Available from: https://www.nichd.nih.gov/health/topics/infertility/conditioninfo/treatments#f1
IX. Sharma RS, Saxena R, Singh R. Infertility & assisted reproduction: A historical & modern scientific perspective. DOAJ (DOAJ: Directory of Open Access Journals) [Internet]. 2018 Dec 1;148(Suppl):S10–4. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469376/
X. Jain M, Singh M. Assisted Reproductive Technology (ART) techniques [Internet]. StatPearls - NCBI Bookshelf. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576409/
XI. Elective Single-embryo Transfer (ESET) [Internet]. ReproductiveFacts.org. Available from: https://www.reproductivefacts.org/news-and-publications/fact-sheets-and-infographics/why-would-i-choose-to-have-elective-single-embryo-transfer-eset/
XII. Chamayou S, Giacone F, Cannarella R, Guglielmino A. What does intracytoplasmic sperm injection change in embryonic development? the spermatozoon contribution. Journal of Clinical Medicine [Internet]. 2023 Jan 14;12(2):671. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867417/
XIII. Brown A, McCarthy HE. The Effect of CoQ10 supplementation on ART treatment and oocyte quality in older women. Human Fertility [Internet]. 2023 Apr 27;26(6):1544–52. Available from: https://pubmed.ncbi.nlm.nih.gov/37102567/
XIV. Singh K, Dewani D. Recent advancements in in vitro fertilisation. Cureus [Internet]. 2022 Oct 10; Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644046/
XV. Guahmich NL, Borini E, Zaninović N. Improving outcomes of assisted reproductive technologies using artificial intelligence for sperm selection. Fertility and Sterility [Internet]. 2023 Oct 1;120(4):729–34. Available from:
https://www.sciencedirect.com/science/article/abs/pii/S0015028223005976
XVI. Gracia CR, Chang J, Kondapalli LA, Prewitt M, Carlson CA, Mattei P, et al. Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration. Journal of Assisted Reproduction and Genetics [Internet]. 2012 Apr 1;29(6):495–502. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370042/
XVII. Lescano S. (Methods in Molecular Biology 1257) Willem F. Wolkers, Harriëtte Oldenhof (Eds.)-Cryopreservation and Freeze-Drying Protocols-Springer-Verlag New York (2015) (1) [Internet]. Scribd. Available from:
XVIII. Shi Q, Xie Y, Wang Y, Li S. Vitrification versus slow freezing for human ovarian tissue cryopreservation: a systematic review and meta-anlaysis. Scientific Reports [Internet]. 2017 Aug 17;7(1). Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561141/
XIX. Prasath EB. Ovarian tissue cryopreservation: An update. Journal of Human Reproductive Sciences [Internet]. 2008 Jan 1;1(2):50. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700672/
XX. Marcantonini G, Bartolini D, Zatini L, Costa S, Passerini M, Rende M, et al. Natural cryoprotective and cytoprotective agents in cryopreservation: A focus on melatonin. Molecules [Internet]. 2022 May 19;27(10):3254. Available from: https://www.mdpi.com/1420-3049/27/10/3254
XXI. Lee S, Cho HW, Kim B, Lee JK, Kim T. The Effectiveness of Anti-Apoptotic Agents to Preserve Primordial Follicles and Prevent Tissue Damage during Ovarian Tissue Cryopreservation and Xenotransplantation. International Journal of Molecular Sciences [Internet]. 2021 Mar 3;22(5):2534. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961474/
XXII. Casciani V, Monseur B, Cimadomo D, Alvero RJ, Rienzi L. Oocyte and embryo cryopreservation in assisted reproductive technology: past achievements and current challenges. Fertility and Sterility [Internet]. 2023 Sep 1;120(3):506–20. Available from:
https://www.sciencedirect.com/science/article/abs/pii/S0015028223005939
XXIII. Lee S, Özkavukçu S, Ku SY. Current and future perspectives for improving ovarian tissue cryopreservation and transplantation outcomes for cancer patients. Reproductive Sciences [Internet]. 2021 Mar 31;28(6):1746–58. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144135/
XXIV. Jin Y, Li S, Q Y, Chen T, Liu D. Application of stem cells in regeneration medicine. MedComm [Internet]. 2023 Jun 17;4(4). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276889/
XXV. Xu M, Shaw G, Murphy M, Barry F. Induced pluripotent stem Cell-Derived mesenchymal stromal cells are functionally and genetically different from bone Marrow-Derived mesenchymal stromal cells. Stem Cells [Internet]. 2019 Mar 6;37(6):754–65. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591688/
XXVI. Ali I, Padhiar AA, Wang T, He L, Chen M, Wu S, et al. Stem Cell-Based therapeutic Strategies for Premature ovarian insufficiency and infertility: A focus on aging. Cells [Internet]. 2022 Nov 22;11(23):3713. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738202/
XXVII. Bodke VV, Burdette JE. Advancements in microfluidic systems for the study of female reproductive biology. Endocrinology [Internet]. 2021 Apr 14;162(10). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571709/
XXVIII. Ding X, Schimenti JC. Strategies to identify genetic variants causing infertility. Trends in Molecular Medicine [Internet]. 2021 Aug 1;27(8):792–806. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263794/
XXIX. Fertility NI. OVARIAN PRP [Internet]. Nova IVF Fertility. 2023. Available from:
https://www.novaivffertility.com/case-study/ovarian-prp
XXX. Chen J, La Roche LATD, Kahlert UD, Isachenko V, Huang H, Hennefründ J, et al. Artificial ovary for young female breast cancer patients. Frontiers in Medicine [Internet]. 2022 Mar 17;9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969104/