Current Approaches in the Management of Monoclonal Gammopathies: an approach to Waldenström Macroglobulinemia

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Isai Gallegos Gomez
Jennifer Aida Ortega Romero
Daniela Denisse Torreros Lara
Rodrigo Garcia Gonzalez
Carmen Sabrina Campaña Medina
Ariadna Melissa Alonso Padilla
Abel Gallegos Aguilar
Eotoniel Sanchez Romero

Abstract

Monoclonal gammopathies encompass a spectrum of disorders characterized by the abnormal proliferation of plasma cells, leading to the production of monoclonal immunoglobulins. Waldenström macroglobulinemia (WM) is a rare, indolent lymphoproliferative disorder characterized by the presence of an IgM monoclonal gammopathy, bone marrow infiltration by lymphoplasmacytic cells, and clinical features such as hyperviscosity, lymphadenopathy, and hepatosplenomegaly. Recent advances in understanding the pathogenesis of WM have led to the development of novel therapeutic strategies, including targeted therapies and immunomodulatory agents, which have significantly improved outcomes for patients. This article provides an overview of the current understanding of WM pathophysiology, clinical presentation, diagnostic approach, and recent advancements in its management.

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How to Cite
Isai Gallegos Gomez, Jennifer Aida Ortega Romero, Daniela Denisse Torreros Lara, Rodrigo Garcia Gonzalez, Carmen Sabrina Campaña Medina, Ariadna Melissa Alonso Padilla, Abel Gallegos Aguilar, & Eotoniel Sanchez Romero. (2024). Current Approaches in the Management of Monoclonal Gammopathies: an approach to Waldenström Macroglobulinemia. International Journal of Medical Science and Clinical Research Studies, 4(03), 363–368. https://doi.org/10.47191/ijmscrs/v4-i03-01
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