Diagnosis of Pulmonary Candida Non-albican in Immunocompetent Patient
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Abstract
Back ground: Pulmonary candidiasis is a fungal airway infection caused by the genus candida species, often in immunocompromised patients, and it spreads through hematogenous or other diseases. This case report aims to inform that the disease is rare in immunocompetent patients and difficult to diagnose.
Methods: Through a medical record search, a 40-year-old Indo-Chinese man complained of chest pain, cough, shortness of breath, and a lump in the neck. A history of pulmonary tuberculosis was completed after six months of treatment with no diabetes mellitus. Then, wheezing and rhonchi were heard during the physical examination of the lungs. When a contrast HRCT (high resolution computed tomography) examination was performed, fibrocalcification with a tree in a bud was found in the bilateral superior lobes of the lung, solid mass in the distal bronchus with atelectasis and enlarged paratracheal nodules. Then, a fungal culture of the right BAL (bronchoalveolar lavage) sample was found candida-non albican.
Conclusion: Pulmonary candidiasis is not only common in immunocompromised patients but also in immunocompetent conditions; diagnosis using HRCT with contrast and fungal culture from BAL.
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References
I. World health organization. The top 10 causes of death. 2020. (cited 12 february 2024). Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
II. Rafat Z, Hashemi SJ, Ashrafi K, et al. Epidemiology, laboratory diagnosis and clinical aspects of fungal pulmonary infections in 384 patients hospitalized in pulmonary units in Guilan province, Iran. National library medicine. 2020. (cited 14 february 2024). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502145/
III. Santos ALS, Branquinha MH, Kneipp LF, and Roudbary M. The book of fungal pathogens. New York. Nova medicine and health. 2023. 424
IV. Wahyu R, Adawiyah R, Sjam R, et al. Seriuos fungal disease incidence and prevalence in Indonesia. National library medicine. 2021. (cited 12 february 2024). Available from: https://pubmed.ncbi.nlm.nih.gov/33971053/
V. Zimmerman JJ, Clark RSB, Fuhrman BP, et al. Fuhrman and Zimmerman’s pediatric critical care. 6th ed. Canada. Elsevier. 2022. 599
VI. Ernst JD, Jr TEK, Lazarus SC, et al. Murray & Nadel’s Textbook of Respiratory Medicine. 7th ed. Canada. Elsevier. 2022. 767 and 768
VII. Hospenthal DR, Rinaldi MG, and Walsh TJ. Diagnosis and treatment of fungal infections. 3rd ed. USA. Springer. 84-86 and 151
VIII. Lealie KO and Wick MR. Practical Pulmonary Pathology A Diagnostic Approach. 3rd ed. Philadelphia. Elsevier. 2018. 185
IX. Center for disease control and prevention. Invasive Candidiasis Risk & Prevention. 2020. (cited 13 february 2024). Available from: https://www.cdc.gov/fungal/diseases/candidiasis/invasive/risk-prevention.html
X. Miroslaw M, Montewka MK, Chudnicka A, Milczak A, and Jablonka S. Candida colonization in lung cancer patients and its role as a prognostic factor for infection occurrence during hospitalization. 2003. (cited 12 february 2024). Available from: https://www.ers-education.org/lr/show-details/?idP=23140
XI. Fishani MH, Shakerimoghaddam A, and Khaledi A. Candida coinfection among patients with pulmonary tuberculosis in Asia and Africa; A systematic review and meta-analysis of cross-sectional studies. 2019. (cited 13 february 2024). Available from: https://pubmed.ncbi.nlm.nih.gov/31794817/
XII. Kali A, Charled MVP, Noyal MJ, et al. Prevalence of Candida co-infection in patients with pulmonary tuberculosis. 2013. (cited 13 february 2024). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767025/
XIII. Ali Y, Mousa A, Mohamed H, Ibrahim M, Naveed M, and Alsamawi M. Candida pneumonia in young and immunocompetent lady: A case report and literature review. 2023. (cited 12 february 2024). Available from: https://www.sciencedirect.com/science/article/pii/S2214250923001646
XIV. Erum R, Samad F, Khan A, and Kazmi SU. A comparative study on production of extracellular hydrolytic enzymes of Candida species isolated from patients with surgical site infection and from healthy individuals and their co-relation with antifungal drug resistance. 2020. (cited 12 february 2024). Available from: https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-020-02045-6
XV. Han TL, Cannon RD, and Villas-Bôas SG. The metabolic basis of Candida albicans morphogenesis and quorum sensing. 2011. (cited 13 february 2024). Available from: https://pubmed.ncbi.nlm.nih.gov/21513811/
XVI. Kimura LH and Pearsall NN. Relationship between germination of Candida albicans and increased adherence to human buccal epithelial cells. 1980. (cited 13 february 2024) available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC550958/
XVII. Cannon RD, Holmes AR, Mason AB, and Monk BC. Oral Candida: clearance, colonization, or candidiasis?. 1995. (cited 13 february 2024). Available from: https://pubmed.ncbi.nlm.nih.gov/7790592/
XVIII. Pendleton KM, Huffnagle GB, and Dickson RP. The significance of Candida in the human respiratory tract: our evolving understanding. 2017. (cited 12 february 2024). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433300/#bib52
XIX. Biswas S, Dijck PV, and Datta A, Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans. 2007. (cited 12 february 2024). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899878/
XX. Alves R, Antunes CB, Casal M. Brown AJP, Dijk PV, and Paiva S. Adapting to survive: How Candida overcomes host-imposed constraints during human colonization. 2020. (cited 12 february 2024). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241708/
XXI. Zhou Y, Cheng L, Lei YL, Ren B, and Zhou X. The Interactions Between Candida albicans and Mucosal Immunity. 2021. (cited 13 february 2024). Available from: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.652725/full
XXII. Hidalgo JA and Vazquez JA. Candidiasis. 2023. (cited 13 february 2024). Available from: https://emedicine.medscape.com/article/213853-overview
XXIII. Liu J, Yu YT, Xu CH, and Chen DC. Candida Colonization in the Respiratory Tract: What Is the Significance?. 2021. (cited 13 february 2024). Available from: https://www.frontiersin.org/articles/10.3389/fmed.2020.598037/full
XXIV. Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, and Hotez PJ. Feigin and cherry’s textbook of Pediatric infectious diseases. 8th ed. Philadelphia. Elsevier. 2019. 2034
XXV. Rosyid AN, Marhana IA, and Hasan H. Bunga rampai kedokteran respirasi 2020. Surabaya. Airlangga university press. 2020. 21
XXVI. Bono VD, Delfino ED, Furfaro E, et al. Clinical Performance of the (1,3)-β-D-Glucan Assay in Early Diagnosis of Nosocomial Candida Bloodstream Infections. 2011. (cited 13 february 2024). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232688/
XXVII. Kontoyiannis DP, Reddy BT, Torres HA, et al. Pulmonary Candidiasis in Patients with Cancer: An Autopsy Study. 2002. (cited 13 february 2024). Available from: https://academic.oup.com/cid/article/34/3/400/390259?login=false
XXVIII. Zander, DS and Frver CF. Pulmonary pathology: A volume in the series foundations in diagnostic pathology. 2nd. Philadelpia. 2018. 223-225
XXIX. Souza CA, Müller NL, Marchiori E, Escuissato DL, and Franquet T. Pulmonary invasive aspergillosis and candidiasis in immunocompromised patients: a comparative study of the high-resolution CT findings. 2006. (cited 13 february 2024). Available from: https://pubmed.ncbi.nlm.nih.gov/16915062/
XXX. Pappas PG, Kauffman CA, Andes DR, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by IDSA. 2015. (cited 13 february 2024). Available from: https://www.idsociety.org/practice-guideline/candidiasis/#null