Alagille Syndrome and Associated Cardiac Pathologies: A Comprehensive Exploration of the Interplay between Genetic Factors and Cardiovascular Manifestations

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Consuelo Alejandra Aguirre González
Hayil, Linaldi Sierra
Marcos Vela Rivera
Ruiz Gómez María Fernanda
Francisco Alejandro González Orozco
Sandoval Correa Santiago
Roberto de Jesus Martinez Camacho
Fernando Vázquez Rivera
Mercado Valero Silvia Selene
Estefanía García Alba

Abstract

Alagille Syndrome (ALGS) stands as a multifaceted genetic disorder renowned for its distinctive cholestatic liver disease and characteristic facial features. Beyond the hepatic implications, ALGS has been increasingly recognized for its intricate association with a spectrum of congenital heart diseases, presenting a challenging clinical scenario. This article elucidates the complex interrelation between Alagille Syndrome and various cardiac anomalies, delving into the underlying genetic mechanisms and clinical implications. By synthesizing current research, we aim to enhance the understanding of clinicians and researchers regarding the nuanced cardiovascular manifestations of Alagille Syndrome, paving the way for improved diagnostic strategies and targeted interventions.

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How to Cite
Consuelo Alejandra Aguirre González, Hayil, Linaldi Sierra, Marcos Vela Rivera, Ruiz Gómez María Fernanda, Francisco Alejandro González Orozco, Sandoval Correa Santiago, Roberto de Jesus Martinez Camacho, Fernando Vázquez Rivera, Mercado Valero Silvia Selene, & Estefanía García Alba. (2023). Alagille Syndrome and Associated Cardiac Pathologies: A Comprehensive Exploration of the Interplay between Genetic Factors and Cardiovascular Manifestations. International Journal of Medical Science and Clinical Research Studies, 3(12), 3240–3243. https://doi.org/10.47191/ijmscrs/v3-i12-55
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