Sleep Deprivation and its Impact on the Immune System: Unraveling the Complex Interplay
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Abstract
Sleep deprivation, a prevalent modern-day challenge, has emerged as a critical factor influencing various facets of health, including the immune system. This article delves into the intricate relationship between sleep and immune function, exploring the multifaceted effects of sleep deprivation on immune response modulation. Through an extensive review of current scientific literature, this work aims to shed light on the molecular and cellular mechanisms underpinning the interplay between sleep disruption and immunological changes. Additionally, it discusses the clinical implications of compromised immune function due to inadequate sleep, emphasizing the need for further research and awareness in this evolving field.
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References
I. Luyster FS, et al. Sleep: a health imperative. Sleep. 2012;35:727–734.
II. Grandner MA. Sleep, health, and society. Sleep. Med. Clin. 2017;12:1–22.
III. Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep. 2004;27:1255–1273.
IV. Galland BC, Taylor BJ, Elder DE, Herbison P. Normal sleep patterns in infants and children: a systematic review of observational studies. Sleep. Med. Rev. 2012;16:213–222.
V. Galland, B. C. et al. Establishing normal values for pediatric nighttime sleep measured by actigraphy: a systematic review and meta-analysis. Sleep41, 10.1093/sleep/zsy017 (2018).
VI. Boulos MI, et al. Normal polysomnography parameters in healthy adults: a systematic review and meta-analysis. Lancet Respir. Med. 2019;7:533–543.
VII. Consensus Conference P, et al. Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: methodology and discussion. J. Clin. Sleep. Med. 2015;11:931–952.
VIII. Consensus Conference P, et al. Recommended amount of sleep for a healthy adult: a Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J. Clin. Sleep. Med. 2015;11:591–592.
IX. Carskadon MA, Vieira C, Acebo C. Association between puberty and delayed phase preference. Sleep. 1993;16:258–262.
X. Gulia KK, Kumar VM. Sleep disorders in the elderly: a growing challenge. Psychogeriatrics. 2018;18:155–165.
XI. Garbarino S, Lanteri P, Sannita WG, Bragazzi NL, Scoditti E. Circadian rhythms, sleep, immunity, and fragility in the elderly: the model of the susceptibility to infections. Front. Neurol. 2020;11:558417.
XII. Zomers, M. L. et al. Characterizing adult sleep behavior over 20 years-the Population-Based Doetinchem Cohort Study. Sleep40, 10.1093/sleep/zsx085 (2017). [PMC free article] [PubMed]
XIII. American Academy of Sleep Medicine. International Classification Of Sleep Disorders 3rd edn (American Academy of Sleep Medicine, 2014).