Dupuytren's Disease: A Comprehensive Review of Pathogenesis, Clinical Manifestations, and Therapeutic Strategies

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José Antonio Soto Sánchez
Josué Alvarado Romero
Ximena Minjares Uribe
Alondra Rios Valdés
Leslie Daniela Torres Valdovinos
Anel Santana Ruiz
Carlos Fernando Uc Chi
Vanessa Iliana Palacios Raya

Abstract

Dupuytren's disease, a fibroproliferative disorder of the hand, remains a challenging pathology with significant impact on hand function and quality of life. This article provides a thorough examination of the intricate pathogenesis underlying Dupuytren's disease, delving into the molecular and cellular mechanisms driving abnormal collagen deposition in the palmar fascia. A detailed analysis of the clinical manifestations, from early nodules to advanced contractures, sheds light on the progressive nature of this condition. Furthermore, we explore the intricate interplay between genetic predisposition, environmental factors, and Dupuytren's disease, unraveling the multifaceted etiological landscape.


This review synthesizes current diagnostic modalities, emphasizing the importance of advanced imaging techniques and biomarkers for accurate and timely assessment. Additionally, we discuss both conservative and surgical interventions, highlighting emerging therapeutic strategies such as enzyme-based therapies, gene therapies, and novel surgical approaches. The article aims to provide clinicians, researchers, and healthcare professionals with a comprehensive understanding of Dupuytren's disease, fostering a nuanced approach to diagnosis and management.


 

Article Details

How to Cite
José Antonio Soto Sánchez, Josué Alvarado Romero, Ximena Minjares Uribe, Alondra Rios Valdés, Leslie Daniela Torres Valdovinos, Anel Santana Ruiz, Carlos Fernando Uc Chi, & Vanessa Iliana Palacios Raya. (2023). Dupuytren’s Disease: A Comprehensive Review of Pathogenesis, Clinical Manifestations, and Therapeutic Strategies. International Journal of Medical Science and Clinical Research Studies, 3(11), 2889–2893. https://doi.org/10.47191/ijmscrs/v3-i11-65
Section
Articles
Author Biography

José Antonio Soto Sánchez, Facultad de Medicina Universidad Nacional Autónoma de Mexico. Ciudad Universitaria.

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