Evaluation of Thyroperoxidase and TSH Receptor Autoantibodies in Thyroid Dysfunction Patients
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Abstract
Thyroid autoimmune disease is one of the most common disorders which are generally associated with existence of anti-thyroid peroxidase (TPO) in addition to ant thyroid stimulating hormone receptor (TSHR) antibodies, and anti-thyroglobulin (Tg). The present study was a cross-sectional one, conducted on (200) patients selected randomly from cases already diagnosed with thyroid disorder diseases by a specialized endocrinology center in AL-Basra city / Iraq. Where TPO test was performed for 127 of them, and TRAB test was conducted for the remaining 73 patients. The study showed that 74% of the cases that had a TPO test were positive, and 49% of the cases that had a TRAB test were also positive. The study also showed that the percentage of people with hypothyroidism was higher in those who had positive TPO results, in contrast to those who had positive TRAB results, where hyperthyroidism was the dominant disease.
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References
I. Cooper, Glinda S, and Berrit C Stroehla. 2003. “The Epidemiology of Autoimmune Diseases.” Autoimmunity Reviews 2 (3): 119–25.
II. Fröhlich, Eleonore, and Richard Wahl. 2017. “Thyroid Autoimmunity: Role of Anti-Thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases.” Frontiers in Immunology 8: 521.
III. Kaczur, V, Gy Vereb, I Molnar, G Krajczar, E Kiss, N R Farid, and Cs Balazs. 1997. “Effect of Anti-Thyroid Peroxidase (TPO) Antibodies on TPO Activity Measured by Chemiluminescence Assay.” Clinical Chemistry 43 (8): 1392–96.
IV. Marcocci, Claudio, and Michele Marino. 2005. “Thyroid Directed Antibodies.”
V. Matthews, David C, and Akheel A Syed. 2011. “The Role of TSH Receptor Antibodies in the Management of Graves’ Disease.” European Journal of Internal Medicine 22 (3): 213–16.
VI. McLachlan, Sandra M, and Basil Rapoport. 1992. “The Molecular Biology of Thyroid Peroxidase: Cloning, Expression and Role as Autoantigen in Autoimmune Thyroid Disease.” Endocrine Reviews 13 (2): 192–206.
VII. Thiel, Jacqueline, Christina Alter, Sina Luppus, Anja Eckstein, Susanne Tan, Dagmar Führer, Eva Pastille, Astrid M Westendorf, Jan Buer, and Wiebke Hansen. 2019. “MicroRNA-183 and MicroRNA-96 Are Associated with Autoimmune Responses by Regulating T Cell Activation.” Journal of Autoimmunity 96: 94–103.
VIII. Tozzoli, R, M Bagnasco, D Giavarina, and N Bizzaro. 2012. “TSH Receptor Autoantibody Immunoassay in Patients with Graves’ Disease: Improvement of Diagnostic Accuracy over Different Generations of Methods. Systematic Review and Meta-Analysis.” Autoimmunity Reviews 12 (2): 107–13.