Latent Autoimmune Diabetes of Adults Presenting as Recurrent Diabetic Ketoacidosis

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Published: Nov 30, 2024
DOI: https://doi.org/10.47191/ijmscrs/v4-i11-39

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Shankarappa R S
Professor, Department of General Medicine, Sri Siddhartha Medical College Hospital and Research Centre, Tumakuru, Karnataka.
N Manoj kumar
Resident, Department of General Medicine, Sri Siddhartha Medical College Hospital and Research Centre, Tumakuru, Karnataka.

Abstract

Diabetes mellitus encompasses a spectrum of metabolic disorders characterized by
hyperglycaemia, resulting from genetic and environmental interactions that impair insulin
secretion, glucose utilization, and production. The World Health Organization  revised
its diabetes classification in 2019 to include six categories: Type 1 -insulin-dependent, Type
2 -insulin-resistant, hybrid forms  e.g., Latent Autoimmune Diabetes in Adults -LADA and
ketosis-prone diabetes, other specific types, unclassified diabetes, and hyperglycaemia first
detected during pregnancy. LADA is a hybrid form of diabetes characterized by gradual
autoimmune beta-cell destruction, commonly misdiagnosed as Type 2 diabetes. Diagnostic
criteria include onset after 30 years, islet autoantibodies e.g., GAD, and delayed insulin
dependence. LADA risk factors include low BMI, autoimmune history, and progressive
hyperglycaemia despite oral antidiabetic therapy. High-risk patients undergo GAD antibody
testing for confirmation. Accurate identification of LADA is essential for appropriate
management, as it bridges features of Type 1 and Type 2 diabetes.

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How to Cite
R S, S. ., & Nallabothula Manoj Kumar. (2024). Latent Autoimmune Diabetes of Adults Presenting as Recurrent Diabetic Ketoacidosis. International Journal of Medical Science and Clinical Research Studies, 4(11), 2105–2107. https://doi.org/10.47191/ijmscrs/v4-i11-39
Issue
Vol. 4 No. 11 (2024): Volume 04 Issue 11 November 2024
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biography

N Manoj kumar , Resident, Department of General Medicine, Sri Siddhartha Medical College Hospital and Research Centre, Tumakuru, Karnataka.

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